TMPZnCl•LiCl: A New Active Selective Base for the Directed Zincation of Sensitive Aromatics and Heteroaromatics

被引：163

作者：

Mosrin, Marc ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 08期

基金：

欧洲研究理事会;

关键词：

METAL-MEDIATED ZINCATION; MAGNESIUM AMIDE BASES; C-H BONDS; CHEMOSELECTIVE BASE; DIAZINES PYRIDINES; EXCHANGE-REACTION; GENERAL-METHOD; TMP-ZINCATE; FUNCTIONALIZATION; DEPROTONATION;

D O I：

10.1021/ol900342a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using TMPZnCl center dot LiCl, a new exceptionally mild and efficient base. Activated arenes and heteroarenes are metalated at room temperature. Remarkably, sensitive functions such as an aldehyde as well as a nitro group are tolerated, expanding significantly the scope of directed metalations.

引用

页码：1837 / 1840

页数：4

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