Overview of new anti-depressants

This is a review of accumulated laboratory and clinical information on new anti-depressants, focusing on selective serotonin reuptake inhibitors, the serotonin and norepinephrine reuptake inhibitor, reversible inhibitor of monoamine oxidase-A, and bupropion with particular emphasis on their pharmacokinetics, indications, dosages, precautions, adverse effects and drug interactions. We conclude that these new anti-depressants may offer improvement in side-effect profile and safety in overdose but not necessarily in the overall rate of improvement.