Imaging the penumbra - strategies to detect tissue at risk after ischemic stroke

被引：32
作者：
Ebinger, M. [1 ]
De Silva, D. A. [1 ]
Christensen, S. [1 ]
Parsons, M. W. [1 ]
Markus, R. [1 ]
Donnan, G. A. [1 ]
Davis, S. M. [1 ]
机构：
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Parkville, Vic 3050, Australia
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 02期
关键词：
Penumbra; Stroke; PET; SPECT; MRI; CT; Clinical-diffusion mismatch; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-ARTERY OCCLUSION; DIFFUSION-WEIGHTED MRI; CLINICAL-DIFFUSION; PERFUSION-CT; PLASMINOGEN ACTIVATOR; THROMBOLYTIC THERAPY; COMPUTED-TOMOGRAPHY; BRAIN RECOVERY; INFARCT CORE;
D O I：
10.1016/j.jocn.2008.04.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of thrombolytic therapy after acute ischemic stroke is salvage of the ischemic penumbra. Several imaging techniques have been used to identify the penumbra in patients who may benefit from reperfusion beyond the currently narrow 3-hour time-window for thrombolysis. We discuss the advantages and disadvantages of positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI and CT scans. We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials. (c) 2008 Published by Elsevier Ltd.
引用
收藏
页码：178 / 187
页数：10
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