TERT-Regulation and Roles in Cancer Formation

被引：219

作者：

Dratwa, Marta ^{[1
]}

Wysoczanska, Barbara ^{[1
]}

Lacina, Piotr ^{[1
]}

Kubik, Tomasz ^{[2
]}

Bogunia-Kubik, Katarzyna ^{[1
]}

机构：

[1] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Lab Clin Immunogenet & Pharmacogenet, Wroclaw, Poland

[2] Wroclaw Univ Sci & Technol, Fac Elect, Dept Comp Engn, Wroclaw, Poland

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

telomerase reverse transcriptase; cancer progression; TERTp mutations; telomere maintenance mechanisms; TERT structural variants; TERT epigenetic alterations; TERT transcriptional activators and repressors; TELOMERASE REVERSE-TRANSCRIPTASE; CATALYTIC SUBUNIT HTERT; PROMOTER DNA METHYLATION; SPLICE VARIANTS; DISEASE RECURRENCE; TARGETING HTERT; BLADDER-CANCER; MESSENGER-RNA; GENE PROMOTER; BRAF V600E;

D O I：

10.3389/fimmu.2020.589929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms. Telomere maintenance mechanisms include complex TERT changes such as gene amplifications, TERT structural variants, TERT promoter germline and somatic mutations, TERT epigenetic changes, and alternative lengthening of telomere. All of them are cancer specific at tissue histotype and at single cell level. TERT expression is regulated in tumors via multiple genetic and epigenetic alterations which affect telomerase activity. Telomerase activity via TERT expression has an impact on telomere length and can be a useful marker in diagnosis and prognosis of various cancers and a new therapy approach. In this review we want to highlight the main roles of TERT in different mechanisms of cancer development and regulation.

引用

页数：16

共 214 条

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