Management of Pseudomonas aeruginosa pneumonia: one size does not fit all

被引：6

作者：

Rello, Jordi ^{[1
,2
,3
,4
]}

Borgatta, Barbara ^{[1
,3
]}

Lagunes, Leonel ^{[1
,3
]}

机构：

[1] Hosp Valle De Hebron, Crit Care Dept, Barcelona 08035, Spain

[2] Recinto Hosp Joan March, CIBERES, Bunyola, Illes Balears, Spain

[3] Vall dHebron Inst Res, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, E-08193 Barcelona, Spain

来源：

CRITICAL CARE | 2014年 / 18卷 / 02期

关键词：

VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE-CARE UNITS; RISK-FACTORS; CLINICAL-OUTCOMES; INFECTION; PREVALENCE; STRATEGIES; SEROTYPES; THERAPY;

D O I：

10.1186/cc13849

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

In view of the mortality associated with Pseudomonas aeruginosa (PSA) ventilator-associated pneumonia (VAP) and the frequency of inadequate initial empiric therapy, recent findings underscore the need for a different management paradigm with effective anti-pseudomonal vaccines for prophylaxis of patients at risk. The association of virulence factors is a variable that splits PSA in two phenotypes, with the possibility of adjunctive immunomodulatory therapy for management of virulent strains. We comment on recent advances in and the state of the art of PSA-VAP management and discuss a new paradigm for tailored and optimal management.

引用

页数：2

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