New 3-O-acyl betulinic acids from Strychnos vanprukii Craib

被引：33

作者：

Chien, NQ

Van Hung, N

Santarsiero, BD

Mesecar, AD

Cuong, NM

Soejarto, DD

Pezzuto, JM

Fong, HHS

Tan, GT

机构：

[1] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Ctr Pharmaceut Biotechnol, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60607 USA

[3] Natl Ctr Sci & Technol, Inst Chem, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 06期

关键词：

D O I：

10.1021/np030469i

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new betulinic acid derivatives, 3beta-O-trans-feruloylbetulinic acid (1), 3beta-O-cis-feruloylbetulinic acid (2), and 3beta-O-cis-coumaroylbetulinic acid (4), along with two known triterpenes, 3beta-O-trans-coumaroylbetulinic acid (3) and ursolic acid (6) were isolated from the leaves and twigs of Strychnos vanprukii Craib. All isolates showed moderate anti-HIV activity with IC50 values ranging from 3 to 7 mug/mL (5 to 15 muM) in an indicator cell line for HIV infectivity. The structures of the new isolates were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy. In addition, the structure of 1 was confirmed by X-ray crystallography.

引用

页码：994 / 998

页数：5

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