Ageing: Effects on oxidative function of skeletal muscle in vivo

被引:119
|
作者
Taylor, DJ
Kemp, GJ
Thompson, CH
Radda, GK
机构
[1] UNIV OXFORD,DEPT BIOCHEM,OXFORD OX1 3QU,ENGLAND
[2] OXFORD RADCLIFF HOSP,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT,OXFORD,ENGLAND
基金
英国医学研究理事会;
关键词
ageing; skeletal muscle; bioenergetics; P-31; MRS; mitochondrial function;
D O I
10.1023/A:1006802602497
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
P-31 magnetic resonance spectroscopy studies were carried out on calf muscle of 144 normal male and female subjects age 20-83 years in order to investigate age-related changes in muscle metabolism. Compared to the young adults (20-29 years), oxidative capacity was higher in the children (6-12 years) and was significantly decreased in the elderly (70-83 years). In the adults, the intracellular pH change during exercise diminished with increasing age, resulting in higher calculated free [ADP] and possibly serving as an adaptive mechanism to stimulate mitochondrial ATP production. Children also had higher pH and [ADP] in exercise, but unlike results from the elderly, this was associated with higher oxidative capacity and more rapid metabolic recovery from exercise.
引用
收藏
页码:321 / 324
页数:4
相关论文
共 50 条
  • [1] Ageing: Effects on oxidative function of skeletal muscle in vivo
    D.J. Taylor
    G.J. Kemp
    C.H. Thompson
    G.K. Radda
    Molecular and Cellular Biochemistry, 1997, 174 : 321 - 324
  • [2] Physiology of ageing skeletal muscle and the protective effects of exercise
    Sundberg, Christopher W.
    JOURNAL OF PHYSIOLOGY-LONDON, 2025, 603 (01): : 3 - 6
  • [3] Oxidative proteome alterations during skeletal muscle ageing
    dos Santos, Sofia Lourenco
    Baraibar, Martin A.
    Lundberg, Staffan
    Eeg-Olofsson, Orvar
    Larsson, Lars
    Friguet, Bertrand
    REDOX BIOLOGY, 2015, 5 : 267 - 274
  • [4] Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing
    Zhang, Xiaoyan
    Kunz, Hawley E.
    Gries, Kevin
    Hart, Corey R.
    Polley, Eric C.
    Lanza, Ian R.
    JOURNAL OF PHYSIOLOGY-LONDON, 2021, 599 (14): : 3581 - 3592
  • [5] Reduced oxidative capacity of skeletal muscle mitochondria is a fundamental consequence of adult ageing
    Marcinek, David J.
    Ferrucci, Luigi
    JOURNAL OF PHYSIOLOGY-LONDON, 2025, 603 (01): : 17 - 20
  • [6] Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training
    Salvadego, Desy
    Domenis, Rossana
    Lazzer, Stefano
    Porcelli, Simone
    Rittweger, Joern
    Rizzo, Giovanna
    Mavelli, Irene
    Simunic, Bostjan
    Pisot, Rado
    Grassi, Bruno
    JOURNAL OF APPLIED PHYSIOLOGY, 2013, 114 (11) : 1527 - 1535
  • [7] Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism
    Larson-Meyer, DE
    Newcomer, BR
    Hunter, GR
    Joanisse, DR
    Weinsier, RL
    Bamman, MM
    MUSCLE & NERVE, 2001, 24 (12) : 1665 - 1676
  • [8] Skeletal muscle mitochondrial protein metabolism and function in ageing and type 2 diabetes
    Barazzoni, R
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2004, 7 (01): : 97 - 102
  • [9] Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training
    Chandwaney, R
    Leichtweis, S
    Leeuwenburgh, C
    Ji, LL
    AGE, 1998, 21 (03) : 109 - 117
  • [10] Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training
    Raj Chandwaney
    Steve Leichtweis
    Christiaan Leeuwenburgh
    Li Li Ji
    AGE, 1998, 21 : 109 - 117