THE NEURAL BASIS OF REVERSAL LEARNING: AN UPDATED PERSPECTIVE

被引：415

作者：

Izquierdo, A. ^{[1
]}

Brigman, J. L. ^{[2
]}

Radke, A. K. ^{[3
]}

Rudebeck, P. H. ^{[4
,5
]}

Holmes, A. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, Brain Res Inst, Dept Psychol, Los Angeles, CA 90024 USA

[2] Univ New Mexico, Sch Med, Dept Neurosci, Albuquerque, NM 87131 USA

[3] NIAAA, Lab Behav & Genom Neurosci, Bethesda, MD USA

[4] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

来源：

NEUROSCIENCE | 2017年 / 345卷

关键词：

frontal cortex; striatum; amygdala; dopamine; serotonin; glutamate; MEDIAL PREFRONTAL CORTEX; PRELIMBIC-INFRALIMBIC AREAS; ANTERIOR CINGULATE CORTEX; ORBITOFRONTAL CORTEX; BEHAVIORAL FLEXIBILITY; BASOLATERAL AMYGDALA; DORSOMEDIAL STRIATUM; FRONTAL-CORTEX; SEROTONIN TRANSPORTER; VISUAL-DISCRIMINATION;

D O I：

10.1016/j.neuroscience.2016.03.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reversal learning paradigms are among the most widely used tests of cognitive flexibility and have been used as assays, across species, for altered cognitive processes in a host of neuropsychiatric conditions. Based on recent studies in humans, non-human primates, and rodents, the notion that reversal learning tasks primarily measure response inhibition, has been revised. In this review, we describe how cognitive flexibility is measured by reversal learning and discuss new definitions of the construct validity of the task that are serving as a heuristic to guide future research in this field. We also provide an update on the available evidence implicating certain cortical and subcortical brain regions in the mediation of reversal learning, and an overview of the principal neurotransmitter systems involved. This article is part of a Special issue entitled: Cognitive Flexibility (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：12 / 26

页数：15

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