Effect of topical dexamethasone in reducing dysfunction after facial nerve crush injury in the rat

被引：16
作者：
Jang, Chul Ho [1 ]
Cho, Yong Beom [1 ]
Choi, Cheol Hee [2 ]
Jang, Yoon Seok [2 ]
Jung, Won-Kyo [3 ,4 ]
机构：
[1] Chonnam Natl Univ Hosp, Dept Otolaryngol, Kwangju 501710, South Korea
[2] Chosun Univ, Dept Bio New Drug Dev, Kwangju, South Korea
[3] Pukyong Natl Univ, Dept Biomed Engn, Pusan, South Korea
[4] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol Plus BK21, Pusan, South Korea
来源：
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2014年 / 78卷 / 06期
关键词：
Facial nerve crush; Topical; Dexamethasone; GRANULATION-TISSUE; REGENERATION; MACROPHAGES; RECOVERY; STEROIDS; MODEL; METHYLPREDNISOLONE; DEGENERATION; INFLAMMATION; STIMULATION;
D O I：
10.1016/j.ijporl.2014.03.025
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective: To date, the effect of topical steroid after a crush injury to rat facial nerve has rarely been reported on. The aim of this study was to investigate the effects of topical dexamethasone on recovery after a crush injury to the rat facial nerve, by functional, electrophysiological, and morphological evaluation. Materials and methods: We investigated the effects of topical dexamethasone on recovery after a crush injury to rat facial nerve by functional, electrophysiological and morphological evaluation. Results: The functional recovery using vibrissae movement was significantly high scores in the experimental group than control group at two and three weeks post-crush. The recovery of the threshold of muscle action potential was significantly lowered in the experimental group compared to the control (p < 0.05). However, there was no statistical significance in the nerve conduction velocity. The dexamethasone treatment groups showed a larger axon diameter and thicker myelin sheath than the control group. Conclusion: From our results, topical dexamethasone accelerates recovery of the crush-injured facial nerve. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：960 / 963
页数：4
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