In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

被引：21

作者：

Attia, Mohamed I. ^{[1
,2
]}

Zakaria, Azza S. ^{[3
,4
]}

Almutairi, Maha S. ^{[1
]}

Ghoneim, Soraya W. ^{[1
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Med & Pharmaceut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt

[3] King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia

[4] Univ Alexandria, Dept Microbiol, Fac Pharm, Alexandria 21500, Egypt

来源：

MOLECULES | 2013年 / 18卷 / 10期

关键词：

synthesis; Mannich reaction; azoles; oxime esters; anti-Candida; ANTIFUNGAL ACTIVITY; RESISTANCE; MECHANISMS; IMIDAZOLES;

D O I：

10.3390/molecules181012208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 mu mol/mL being more potent than both fluconazole (MIC > 1.6325 mu mol/mL) and miconazole (MIC value = 0.0188 mu mol/mL) as a new anti-Candida albicans agent.

引用

页码：12208 / 12221

页数：14

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