In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

被引:21
作者
Attia, Mohamed I. [1 ,2 ]
Zakaria, Azza S. [3 ,4 ]
Almutairi, Maha S. [1 ]
Ghoneim, Soraya W. [1 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Med & Pharmaceut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
[3] King Saud Univ, Dept Pharmaceut, Coll Pharm, Riyadh 11451, Saudi Arabia
[4] Univ Alexandria, Dept Microbiol, Fac Pharm, Alexandria 21500, Egypt
关键词
synthesis; Mannich reaction; azoles; oxime esters; anti-Candida; ANTIFUNGAL ACTIVITY; RESISTANCE; MECHANISMS; IMIDAZOLES;
D O I
10.3390/molecules181012208
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 mu mol/mL being more potent than both fluconazole (MIC > 1.6325 mu mol/mL) and miconazole (MIC value = 0.0188 mu mol/mL) as a new anti-Candida albicans agent.
引用
收藏
页码:12208 / 12221
页数:14
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