Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring: Synthesis and antibacterial activity

被引：14

作者：

Bai, Lin Shan ^{[1
]}

Wang, Yan ^{[1
]}

Liu, Xin Hua ^{[1
]}

Zhu, Hai Liang ^{[1
,2
]}

Song, Bao An ^{[3
]}

机构：

[1] Anhui Univ Technol, Key Lab Anhui, Dept Educ, Maanshan 243002, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 04期

关键词：

Synthesis; Multi(hetero)aromatic pyrazole; Antibacterial activity; OXIME ESTER DERIVATIVES; DNA GYRASE INHIBITORS; PYRAZOLE DERIVATIVES; DESIGN; ANALOGS;

D O I：

10.1016/j.cclet.2008.12.013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS, H-1 NMR and C NMR. All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results shove, that compounds 9b, 9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562 mu g/mL against B. subtilis. (C) 2008 Xin Hua Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：427 / 430

页数：4

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