Turmeric and Green Tea: A Recipe for the Treatment of B-Chronic Lymphocytic Leukemia

被引:22
作者
Angelo, Laura S. [1 ]
Kurzrock, Razelle [1 ]
机构
[1] MD Anderson Canc Ctr, Div Canc Med, Phase Clin Trials Program 1, Dept Invest Canc Therapeut, Houston, TX 77030 USA
关键词
LIPOSOME-ENCAPSULATED CURCUMIN; FACTOR-KAPPA-B; IN-VITRO; APOPTOSIS; CANCER; PROLIFERATION; ANGIOGENESIS; CELLS; SUPPRESSION; PATHWAY;
D O I
10.1158/1078-0432.CCR-08-2791
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Two naturally occurring compounds, curcumin, the active ingredient in the spice turmeric, and the green tea extract epigallocatechin-3-gallate, have marked effects on the apoptotic machinery in chronic lymphocytic leukemia. These results provide a preclinical foundation for future clinical use of these compounds in this disease.
引用
收藏
页码:1123 / 1125
页数:3
相关论文
共 13 条
[1]   Phase II trial of curcumin in patients with advanced pancreatic cancer [J].
Dhillon, Navneet ;
Aggarwal, Bharat B. ;
Newman, Robert A. ;
Wolff, Robert A. ;
Kunnumakkara, Ajaikumar B. ;
Abbruzzese, James L. ;
Ng, Chaan S. ;
Badmaev, Vladimir ;
Kurzrock, Razelle .
CLINICAL CANCER RESEARCH, 2008, 14 (14) :4491-4499
[2]   Preclinical assessment of curcumin as a potential therapy for B-CLL [J].
Everett, Peter C. ;
Meyers, John A. ;
Makkinje, Anthony ;
Rabbi, Mohammed ;
Lerner, Adam .
AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (01) :23-30
[3]   Curcumin Inhibits Prosurvival Pathways in Chronic Lymphocytic Leukemia B Cells and May Overcome Their Stromal Protection in Combination with EGCG [J].
Ghosh, Asish K. ;
Kay, Neil E. ;
Secreto, Charla R. ;
Shanafelt, Tait D. .
CLINICAL CANCER RESEARCH, 2009, 15 (04) :1250-1258
[4]  
Gonzales Gustavo F., 2006, Anti-Cancer Agents in Medicinal Chemistry, V6, P429, DOI 10.2174/187152006778226486
[5]   Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia:: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines [J].
Hallek, Michael ;
Cheson, Bruce D. ;
Catovsky, Daniel ;
Caligaris-Cappio, Federico ;
Dighiero, Guillaume ;
Doehner, Hartmut ;
Hillmen, Peter ;
Keating, Michael J. ;
Montserrat, Emili ;
Rai, Kanti R. ;
Kipps, Thomas J. .
BLOOD, 2008, 111 (12) :5446-5456
[6]   Curcumin: From ancient medicine to current clinical trials [J].
Hatcher, H. ;
Planalp, R. ;
Cho, J. ;
Tortia, F. M. ;
Torti, S. V. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (11) :1631-1652
[7]   Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins [J].
Kunnumakkara, Ajaikumar B. ;
Anand, Preetha ;
Aggarwal, Bharat B. .
CANCER LETTERS, 2008, 269 (02) :199-225
[8]   Liposome-encapsulated curcumin - In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis [J].
Li, L ;
Braiteh, FS ;
Kurzrock, R .
CANCER, 2005, 104 (06) :1322-1331
[9]   Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis [J].
Li, L ;
Aggarwal, BB ;
Shishodia, S ;
Abbruzzese, J ;
Kurzrock, R .
CANCER, 2004, 101 (10) :2351-2362
[10]   Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer [J].
Li, Lan ;
Ahmed, Bilal ;
Mehta, Kapil ;
Kurzrock, Razelle .
MOLECULAR CANCER THERAPEUTICS, 2007, 6 (04) :1276-1282