Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry

被引：36

作者：

Flegontov, Pavel ^{[1
,2
,3
]}

Changmai, Piya ^{[1
]}

Zidkova, Anastassiya ^{[1
]}

Logacheva, Maria D. ^{[2
,4
,5
]}

Altinisik, N. Ezgi ^{[1
]}

Flegontova, Olga ^{[3
]}

Gelfand, Mikhail S. ^{[2
,6
]}

Gerasimov, Evgeny S. ^{[2
,4
]}

Khrameeva, Ekaterina E. ^{[2
,7
]}

Konovalova, Olga P. ^{[4
]}

Neretina, Tatiana ^{[4
]}

Nikolsky, Yuri V. ^{[8
,9
]}

Starostin, George ^{[10
,11
]}

Stepanova, Vita V. ^{[2
,7
]}

Travinsky, Igor V.

Triska, Martin ^{[12
]}

Triska, Petr ^{[13
,14
]}

Tatarinova, Tatiana V. ^{[2
,12
,15
]}

机构：

[1] Univ Ostrava, Dept Biol & Ecol, Fac Sci, CZ-70103 Ostrava, Czech Republic

[2] Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow, Russia

[3] Acad Sci Czech Republ, Inst Parasitol, Ctr Biol, Branisovska 31, CR-37005 Ceske Budejovice, Czech Republic

[4] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow, Russia

[5] Pirogov Russian Natl Res Med Univ, Moscow, Russia

[6] Moscow MV Lomonosov State Univ, Fac Bioengn & Bioinformat, Moscow, Russia

[7] Skolkovo Inst Sci & Technol, Skolkovo, Russia

[8] Skolkovo Fdn, Biomed Cluster, Skolkovo, Russia

[9] George Mason Univ, Fairfax, VA 22030 USA

[10] Russian State Univ Humanities, Moscow, Russia

[11] Russian Presidential Acad RANEPA, Moscow, Russia

[12] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[13] Univ Porto IPATIMUP, Inst Patol Imunol Mol, Oporto, Portugal

[14] Univ Porto ICBAS, Inst Ciencias Biomed, Oporto, Portugal

[15] Univ So Calif, Spatial Sci Inst, Los Angeles, CA USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

俄罗斯科学基金会; 美国国家科学基金会;

关键词：

WIDE PATTERNS; POPULATION; SEQUENCE; ORIGIN; TOOL; DNA;

D O I：

10.1038/srep20768

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Kets, an ethnic group in the Yenisei River basin, Russia, are considered the last nomadic hunter-gatherers of Siberia, and Ket language has no transparent affiliation with any language family. We investigated connections between the Kets and Siberian and North American populations, with emphasis on the Mal'ta and Paleo-Eskimo ancient genomes, using original data from 46 unrelated samples of Kets and 42 samples of their neighboring ethnic groups (Uralic-speaking Nganasans, Enets, and Selkups). We genotyped over 130,000 autosomal SNPs, identified mitochondrial and Y-chromosomal haplogroups, and performed high-coverage genome sequencing of two Ket individuals. We established that Nganasans, Kets, Selkups, and Yukaghirs form a cluster of populations most closely related to Paleo-Eskimos in Siberia (not considering indigenous populations of Chukotka and Kamchatka). Kets are closely related to modern Selkups and to some Bronze and Iron Age populations of the Altai region, with all these groups sharing a high degree of Mal'ta ancestry. Implications of these findings for the linguistic hypothesis uniting Ket and Na-Dene languages into a language macrofamily are discussed.

引用

页数：12

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