Determination of Ferulic Acid in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry Method: Application to a Pharmacokinetic Study

被引：7
|
作者：
Zhang, Tianhong [1 ]
Yang, Xiuli [1 ]
Zhang, Peng [1 ]
Zhu, Meng [1 ]
He, Zhonggui [1 ]
Bi, Kaishun [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
来源：
ANALYTICAL LETTERS | 2009年 / 42卷 / 14期
关键词：
Ferulic acid; HPLC-MS/MS; pharmacokinetics; plasma concentration; rat; RHIZOMA-CHUANXIONG; HPLC;
D O I：
10.1080/00032710903137418
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid, sensitive, and specific liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method has been developed for quantification of ferulic acid in rat plasma. The analyte and docetaxel (internal standard) were extracted from plasma samples with diethyl ether and analyzed on a C-18 column. The chromatographic separation was achieved within 3.5 min by using acetonitrile-water as the mobile phase and the flow rate was 0.2mL . min(-1). The method was linear within the range of 0.5 - 800 ng . mL(-1). The lower limit of quantification (LLOQ) was 0.5 ng . mL (1). Finally, the method is successfully applied for the pharmacokinetic study of ferulic acid in rats following intravenous administration.
引用
收藏
页码：2157 / 2169
页数：13
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