Validation of an Enhanced Swift Analytical Method for the Determination of Bound and Free 3-chloropropane-1,2-Diol in Foodstuffs using Gas Chromatography-Tandem Mass Spectrometry

被引：4

作者：

Aboelhassan, AlaaEldean Fathy Ahmed ^{[1
]}

Gomaa, Ahmed Mamdouh I. ^{[1
]}

El-Dien, Faten A. Nour ^{[2
]}

Mohammed, Moustapha N. ^{[1
]}

机构：

[1] Agr Res Ctr ARC, Cent Lab Residue Anal Pesticides & Heavy Met Food, Giza, Egypt

[2] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2020年 / 75卷 / 11期

关键词：

3-monochloropropane-1; 2-diol; enhanced method; triple quadrupole gas chromatography-mass spectrometry; validation; FATTY-ACID ESTERS; SOY-SAUCE; 3-MCPD; 3-CHLORO-1,2-PROPANEDIOL; CHLOROPROPANOLS; 3-MONOCHLOROPROPANE-1,2-DIOL;

D O I：

10.1134/S1061934820110027

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An enhanced swift indirect method for the determination of both free and bound 3-monochloropropane-1,2-diol has been established. The advantages include reduced sample preparation time (1 h instead of several hours), rapid triple quadrupole gas chromatography-mass spectrometry detection (12 min rather than 30 min in average) combined with amplified selectivity and sensitivity. The enhanced method has been entirely validated. The limits of quatification and detection were estimated and were found to be less than 2 and 0.5 mu g/kg, respectively. The recoveries at different spiked levels ranged from 98 to 106%. The reproducibility (expressed as relative standard deviation) was less than 8% while measurement uncertainty was in the range of +/- 18%.

引用

页码：1469 / 1476

页数：8

共 41 条

[1] Rapid and simple determination of chloropropanols (3-MCPD and 1,3-DCP) in food products using isotope dilution GC-MS [J].

Abu-El-Haj, Sameer ;

Bogusz, Maciej J. ;

Ibrahim, Zuhoor ;

Hassan, Huda ;

Al Tufail, Mohammed .

FOOD CONTROL, 2007, 18 (01) :81-90

[2] Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food [J].

Alexander, Jan ;

Contam, Efsa Panel Contaminants Food Chain ;

Barregard, Lars ;

Bignami, Margherita ;

Ceccatelli, Sandra ;

Cottrill, Bruce ;

Dinovi, Michael ;

Edler, Lutz ;

Grasl-Kraupp, Bettina ;

Hogstrand, Christer ;

Hoogenboom, Laurentius ;

Knutsen, Helle Katrine ;

Nebbia, Carlo Stefano ;

Oswald, Isabelle ;

Petersen, Annette ;

Rogiers, Vera Maria ;

Rose, Martin ;

Roudot, Alain-Claude ;

Schwerdtle, Tanja ;

Vleminckx, Christiane ;

Vollmer, Gunter ;

Wallace, Heather .

EFSA JOURNAL, 2016, 14 (05)

[3]

[Anonymous], 2012, Eurachem guide: quantifying uncertainty in analytical measurement, DOI DOI 10.25607/OBP-952

[4]

[Anonymous], 2001, OP SCI COMM FOOD 3 M, V1

[5]

[Anonymous], 2013, IARC MON EV CARC RIS

[6]

Barocelli E., 2011, EFSA SUPP PUBL, V8, p187E

[7]

Barwick V, 2014, FITNESS PURPOSE ANAL

[8] Direct determination of 3-chloro-1,2-propanediol esters in beef flavoring products by ultra-performance liquid chromatography tandem quadrupole mass spectrometry [J].

Chai, Qingqing ;

Zhang, Xiaoming ;

Karangwa, Eric ;

Dai, Qingyuan ;

Xia, Shuqin ;

Yu, Jingyang ;

Gao, Yahui .

RSC ADVANCES, 2016, 6 (114) :113576-113582

[9] Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats [J].

Cho, Wan-Seob ;

Han, Beorn Seok ;

Nam, Ki Taek ;

Park, Kidae ;

Choi, Mina ;

Kim, SeLlng Hee ;

Jeong, Jayoung ;

Jang, Dong Deuk .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (09) :3172-3177

[10]

Commission of the European Communities, 2006, Commission regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs, VL364, P5

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