"One-Shot" Measurement of Residual Chemical Shift Anisotropy Using Poly-γ-benzyl-L-glutamate as an Alignment Medium

被引：13

作者：

Recchia, Michael J. J. ^{[1
]}

Cohen, Ryan D. ^{[2
]}

Liu, Yizhou ^{[3
]}

Sherer, Edward C. ^{[2
]}

Harper, James K. ^{[4
]}

Martin, Gary E. ^{[5
]}

Williamson, R. Thomas ^{[1
]}

机构：

[1] Univ North Carolina Wilmington, Dept Chem & Biochem, Wilmington, NC 28409 USA

[2] Merck & Co Inc, Analyt Res & Dev, Rahway, NJ 07065 USA

[3] Pfizer Worldwide Res & Dev, Analyt Res & Dev, Groton, CT 06340 USA

[4] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

[5] Seton Hall Univ, Dept Chem, S Orange, NJ 07079 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 22期

基金：

美国国家科学基金会;

关键词：

3D STRUCTURE ELUCIDATION; DIPOLAR COUPLINGS; NATURAL-PRODUCTS; RELATIVE CONFIGURATION; LIQUID-CRYSTALS; NMR; COLLECTION; PARAMETERS; MOLECULES; SOLVENT;

D O I：

10.1021/acs.orglett.0c03225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the measurement of residual chemical shift anisotropy in one experiment using a biphasic isotropic/ anisotropic lyotropic liquid crystalline medium based on poly-gamma-benzyl-L-glutamate as the alignment medium is presented. This approach is demonstrated on the model compound strychnine and neotricone, a depsidone natural product with a questionable structural assignment based on comparison with the closely related excelsione and in-depth density functional theory calculations.

引用

页码：8850 / 8854

页数：5

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