Critical role of HMGA proteins in cancer cell chemoresistance

被引：19
作者：
D'Angelo, Daniela [1 ]
Mussnich, Paula [1 ]
Arra, Claudio [2 ]
Battista, Sabrina [1 ]
Fusco, Alfredo [1 ,3 ]
机构：
[1] Ist Endocrinol & Oncol Sperimentale CNR, Via Pansini 5, I-80131 Naples, Italy
[2] IRCCS, Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Naples, Italy
[3] Univ Napoli Federico II, DMMBM, Via Pansini 5, I-80131 Naples, Italy
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 04期
关键词：
HMGA; Chemoresistance; DNA repair; Apoptosis; miRNAs; GROUP-A PROTEINS; PHASE-II TRIAL; TRANSGENIC MICE; DRUG-RESISTANCE; UP-REGULATION; CISPLATIN RESISTANCE; MULTIDRUG-RESISTANCE; COLORECTAL-CANCER; CARCINOMA CELLS; DOWN-REGULATION;
D O I：
10.1007/s00109-017-1520-x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.
引用
收藏
页码：353 / 360
页数：8
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