Critical role of HMGA proteins in cancer cell chemoresistance

被引：19

作者：

D'Angelo, Daniela ^{[1
]}

Mussnich, Paula ^{[1
]}

Arra, Claudio ^{[2
]}

Battista, Sabrina ^{[1
]}

Fusco, Alfredo ^{[1
,3
]}

机构：

[1] Ist Endocrinol & Oncol Sperimentale CNR, Via Pansini 5, I-80131 Naples, Italy

[2] IRCCS, Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Naples, Italy

[3] Univ Napoli Federico II, DMMBM, Via Pansini 5, I-80131 Naples, Italy

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 04期

关键词：

HMGA; Chemoresistance; DNA repair; Apoptosis; miRNAs; GROUP-A PROTEINS; PHASE-II TRIAL; TRANSGENIC MICE; DRUG-RESISTANCE; UP-REGULATION; CISPLATIN RESISTANCE; MULTIDRUG-RESISTANCE; COLORECTAL-CANCER; CARCINOMA CELLS; DOWN-REGULATION;

D O I：

10.1007/s00109-017-1520-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.

引用

页码：353 / 360

页数：8

共 50 条

[11] The role of membrane transporters in ovarian cancer chemoresistance and prognosis
Cerovska, Ela
Elsnerova, Katerina
Vaclavikova, Radka
Soucek, Pavel
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2017, 13 (07) : 741 - 753
[12] The emerging role of noncoding RNAs in colorectal cancer chemoresistance
Wei, Ling
Wang, Xingwu
Lv, Liyan
Zheng, Yan
Zhang, Nasha
Yang, Ming
CELLULAR ONCOLOGY, 2019, 42 (06) : 757 - 768
[13] Extracellular Vesicles and Cell Pathways Involved in Cancer Chemoresistance
Console, Lara
Scalise, Mariafrancesca
LIFE-BASEL, 2022, 12 (05):
[14] The role of DNA methylation in ovarian cancer chemoresistance: A narrative review
Song, Kaiyang
Artibani, Mara
HEALTH SCIENCE REPORTS, 2023, 6 (05)
[15] The role of H19 lncRNA in conferring chemoresistance in cancer cells
Ghafouri-Fard, Soudeh
Shoorei, Hamed
Bahroudi, Zahra
Abak, Atefe
Taheri, Mohammad
BIOMEDICINE & PHARMACOTHERAPY, 2021, 138
[16] The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells
Fu, Yibo
Ricciardiello, Francesca
Yang, Gang
Qiu, Jiangdong
Huang, Hua
Xiao, Jianchun
Cao, Zhe
Zhao, Fangyu
Liu, Yueze
Luo, Wenhao
Chen, Guangyu
You, Lei
Chiaradonna, Ferdinando
Zheng, Lianfang
Zhang, Taiping
CELLS, 2021, 10 (03) : 1 - 33
[17] Autophagy-mediating microRNAs in cancer chemoresistance
Jing, Yuanming
Liang, Wenqing
Liu, Jian
Zhang, Lin
Wei, Jianguo
Yang, Jianhui
Zhang, Yu
Huang, Zongliang
CELL BIOLOGY AND TOXICOLOGY, 2020, 36 (06) : 517 - 536
[18] Cellular and Molecular Mechanisms of Chemoresistance for Gastric Cancer
Li, Zonglin
Shu, Xingming
Liu, Xin
Li, Qiuyun
Hu, Yifu
Jia, Bingbing
Song, Min
INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2024, 17 : 3779 - 3788
[19] Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/ 2 proteins
Doodmani, Seyed Mohammad
Safari, Mohamad Hosein
Akbari, Mohammadarian
Farahani, Najma
Alimohammadi, Mina
Aref, Amir Reza
Tajik, Fatemeh
Maghsoodlou, Amin
Daneshi, Salman
Tabari, Teimour
Taheriazam, Afshin
Entezari, Maliheh
Nabavi, Noushin
Hashemi, Mehrdad
PATHOLOGY RESEARCH AND PRACTICE, 2025, 267 : 155838
[20] ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance
Tsoumas, Dimitrios
Nikou, Sofia
Giannopoulou, Efstathia
Tsaniras, Spyridon Champeris
Sirinian, Chaido
Maroulis, Ioannis
Taraviras, Stavros
Zolota, Vassiliki
Kalofonos, Haralabos P.
Bravou, Vasiliki
CANCER GENOMICS & PROTEOMICS, 2018, 15 (02) : 127 - 141

← 1 2 3 4 5 →