Granulocyte colony-stimulating factor alone at 12 μg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients

被引：30
作者：
Sevilla, J
González-Vicent, M
Madero, L
García-Sánchez, F
Díaz, M
机构：
[1] Hosp Infantil Univ Nino Jesus, Madrid 28009, Spain
[2] Ctr Trasfus Comunidad Madrid, Madrid, Spain
来源：
BONE MARROW TRANSPLANTATION | 2002年 / 30卷 / 07期
关键词：
G-CSF; priming; LVL; children; mobilization;
D O I：
10.1038/sj.bmt.1703662
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In children, the optimal mobilization schedule for harvesting peripheral blood progenitor cells (PBPC) is an issue of continuous research. We have studied a schedule based on high and daily divided doses of G-CSF (12 mug/kg body weight twice daily) for 4 days for PBPC priming. Toxicity related to G-CSF was observed in 13 patients (23%), mainly mild bone pain and myalgia. The median CD34(+) cell number collected was 4.4 (0.4-35 x 10(6)/kg body weight), with 46 patients achieving 2 x 10(6)/kg body weight (83.6%) after a single large volume leukapheresis. In conclusion, this mobilization schedule allows safe and efficient collection of the minimum target CD34(+) cell dose in most pediatric patients by only one procedure.
引用
收藏
页码：417 / 420
页数：4
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