Prediction of plant microRNA targets

被引：1902

作者：

Rhoades, MW

Reinhart, BJ

Lim, LP

Burge, CB

Bartel, B

Bartel, DP

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA

来源：

CELL | 2002年 / 110卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(02)00863-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differentiation. The near-perfect complementarity between plant miRNAs and their targets suggests that many plant miRNAs act similarly to small interfering RNAs and direct mRNA cleavage. The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages.

引用

页码：513 / 520

页数：8

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