Obstructive sleep apnea is independently associated with inflammation and insulin resistance, but not with blood pressure, plasma catecholamines, and endothelial function in obese subjects

被引:36
作者
Araujo, Luciene da Silva [1 ]
Rodrigues Fernandes, Julia Freitas [1 ]
Simas Torres Klein, Marcia Regina [2 ]
Sanjuliani, Antonio Felipe [1 ]
机构
[1] Univ Estado Rio De Janeiro, Discipline Clin & Expt Pathophysiol, Rio De Janeiro, Brazil
[2] Univ Estado Rio De Janeiro, Inst Nutr, Dept Appl Nutr, Rio De Janeiro, Brazil
关键词
Obstructive sleep apnea; Obesity; Endothelial function; Inflammation; Insulin resistance; C-REACTIVE PROTEIN; PERIPHERAL ARTERIAL TONOMETRY; RANDOMIZED CONTROLLED-TRIAL; POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK-FACTOR; HYPERTENSION; MECHANISMS; MARKERS;
D O I
10.1016/j.nut.2015.05.017
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objectives: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD). Several of the proposed mechanisms for the development of CVD in OSA are similar to those proposed for the increased risk of CVD in obesity, so that it is difficult to determine the influence of OSA on these pathogenic mechanisms in obese individuals. The aim of this study was to evaluate the relationship of OSA with endothelial function, oxidative stress, inflammatory biomarkers, metabolic profile, sympathetic nervous system activity, and blood pressure (BP) in obese individuals. Methods: This cross-sectional study included 53 obese adults (28 women). Sleep study was performed with WatchPAT 200 (Itamar Medical, Caesarea, Israel) and the diagnosis of OSA was made when apnea-hypopnea index (AHI) >= 5 events/h (n = 33). All participants underwent evaluation of: body adiposity, BP, plasma catecholamines, high sensitivity C-reactive protein (hs-CRP), adiponectin, malondialdehyde, glucose, insulin, lipid profile, and endothelial function (EndoPAT 2000). Results: In univariate analysis, participants with OSA compared with those without OSA exhibited higher values of neck circumference, glucose, noradrenaline, and systolic BP. After adjustment for confounders, including adiposity, only glucose and hs-CRP were significantly higher in OSA patients. In correlation analysis, after controlling for confounders, AHI was positively and significantly associated with neck circumference and hs-CRP, while minimum 02 saturation was associated negatively and significantly with neck circumference, insulin and homeostatic model assessment insulin resistance (HOMA-IR). Conclusions: The present study suggests that in obese individuals OSA is independently associated with inflammation and insulin resistance, but not with BP, plasma catecholamines and endothelial function. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:1351 / 1357
页数:7
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