Aberrant Wnt Signaling in Leukemia

被引：70
作者：
Staal, Frank J. T. [1 ]
Famili, Farbod [1 ]
Perez, Laura Garcia [1 ]
Pike-Overzet, Karin [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
来源：
CANCERS | 2016年 / 8卷 / 09期
关键词：
Wnt signaling; leukemic stem cell; leukemia; AML; CML; CLL; ALL; pathogenesis; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; SMALL-MOLECULE INHIBITORS; WNT/BETA-CATENIN PATHWAY; TYROSINE KINASE-ACTIVITY; BETA-CATENIN; TUMOR-SUPPRESSOR; BCR-ABL;
D O I：
10.3390/cancers8090078
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment.
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页数：15
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共 101 条
  • [1] Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
    Allman, D
    Karnell, FG
    Punt, JA
    Bakkour, S
    Xu, LW
    Myung, P
    Koretzky, GA
    Pui, JC
    Aster, JC
    Pear, WS
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (01) : 99 - 106
  • [2] Regeneration-associated WNT Signaling Is Activated in Long-term Reconstituting AC133bright Acute Myeloid Leukemia Cells
    Beghini, Alessandro
    Corlazzoli, Francesca
    Del Giacco, Luca
    Re, Matteo
    Lazzaroni, Francesca
    Brioschi, Matteo
    Valentini, Giorgio
    Ferrazzi, Fulvia
    Ghilardi, Anna
    Righi, Marco
    Turrini, Mauro
    Mignardi, Marco
    Cesana, Clara
    Bronte, Vincenzo
    Nilsson, Mats
    Morra, Enrica
    Cairoli, Roberto
    [J]. NEOPLASIA, 2012, 14 (12): : 1236 - +
  • [3] Signaling pathways governing stem-cell fate
    Blank, Ulrika
    Karlsson, Goeran
    Karlsson, Stefan
    [J]. BLOOD, 2008, 111 (02) : 492 - 503
  • [4] Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    Chim, C. S.
    Pang, R.
    Fung, T. K.
    Choi, C. L.
    Liang, R.
    [J]. LEUKEMIA, 2007, 21 (12) : 2527 - 2536
  • [5] Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia
    Chim, C. S.
    Fung, T. K.
    Wong, K. F.
    Lau, J. S.
    Liang, R.
    [J]. LEUKEMIA RESEARCH, 2006, 30 (09) : 1135 - 1139
  • [6] Wnt/β-catenin signaling in development and disease
    Clevers, Hans
    [J]. CELL, 2006, 127 (03) : 469 - 480
  • [7] Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis
    Corces-Zimmerman, M. R.
    Majeti, R.
    [J]. LEUKEMIA, 2014, 28 (12) : 2276 - 2282
  • [8] CANONICAL AND NON-CANONICAL NOTCH LIGANDS
    D'Souza, Brendan
    Meloty-Kapella, Laurence
    Weinmaster, Gerry
    [J]. NOTCH SIGNALING, 2010, 92 : 73 - 129
  • [9] The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    Deininger, M
    Buchdunger, E
    Druker, BJ
    [J]. BLOOD, 2005, 105 (07) : 2640 - 2653
  • [10] Deininger MWN, 2001, CANCER RES, V61, P8005
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