Mechanisms of Disease: Scleroderma.

被引:1191
作者
Gabrielli, Armando [1 ,2 ]
Avvedimento, Enrico V. [3 ]
Krieg, Thomas [4 ]
机构
[1] Univ Politecn Marche, Sect Clin Med, Dept Med Sci & Surg, Ancona, Italy
[2] Osped Riuniti, Ancona, Italy
[3] Univ Naples Federico II, CNR, Inst Endocrinol & Expt Oncol, Dept Mol & Cellular Biol & Pathol, Naples, Italy
[4] Univ Cologne, Dept Dermatol, D-5000 Cologne, Germany
关键词
GROWTH-FACTOR-BETA; PROGRESSIVE SYSTEMIC-SCLEROSIS; ENDOTHELIAL PROGENITOR CELLS; OXYGEN SPECIES PRODUCTION; NADPH OXIDASE COMPLEX; REACTIVE OXYGEN; TGF-BETA; INCREASED EXPRESSION; UP-REGULATION; IN-VITRO;
D O I
10.1056/NEJMra0806188
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1989 / 2003
页数:15
相关论文
共 108 条
[91]   Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis [J].
Servettaz, A. ;
Guilpain, P. ;
Goulvestre, C. ;
Chereau, C. ;
Hercend, C. ;
Nicco, C. ;
Guillevin, L. ;
Weill, B. ;
Mouthon, L. ;
Batteux, F. .
ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1202-1209
[92]   Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma [J].
Sgonc, R ;
Gruschwitz, MS ;
Dietrich, H ;
Recheis, H ;
Gershwin, ME ;
Wick, G .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (03) :785-792
[93]   Dissecting the roles of endothelin, TGF-β and GM-CSF on myofibroblast differentiation by keratinocytes [J].
Shephard, P ;
Hinz, B ;
Smola-Hess, S ;
Meister, JJ ;
Krieg, T ;
Smola, H .
THROMBOSIS AND HAEMOSTASIS, 2004, 92 (02) :262-274
[94]   CUTANEOUS HYPOXIA IN PATIENTS WITH SYSTEMIC-SCLEROSIS (SCLERODERMA) [J].
SILVERSTEIN, JL ;
STEEN, VD ;
MEDSGER, TA ;
FALANGA, V .
ARCHIVES OF DERMATOLOGY, 1988, 124 (09) :1379-1382
[95]  
SNAPPER CM, 1993, J IMMUNOL, V151, P4625
[96]  
Sondergaard K, 1998, BRIT J RHEUMATOL, V37, P304
[97]   Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma [J].
Sonnylal, Sonali ;
Denton, Christopher P. ;
Zheng, Bing ;
Keene, Douglas R. ;
He, Ruming ;
Adams, Henry P. ;
VanPelt, Carolyn S. ;
Geng, Yong J. ;
Deng, Jenny M. ;
Behringer, Richard R. ;
de Crombrugghe, Benoit .
ARTHRITIS AND RHEUMATISM, 2007, 56 (01) :334-344
[98]  
Stellos K, 2008, PHARMACOL REP, V60, P101
[99]   Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells [J].
Stellos, Konstantinos ;
Langer, Harald ;
Daub, Karin ;
Schoenberger, Tanja ;
Gauss, Alexandra ;
Geisler, Tobias ;
Bigalke, Boris ;
Mueller, Iris ;
Schumm, Michael ;
Schaefer, Iris ;
Seizer, Peter ;
Kraemer, Bjoern F. ;
Siegel-Axel, Dorothea ;
May, Andreas E. ;
Lindemann, Stephan ;
Gawaz, Meinrad .
CIRCULATION, 2008, 117 (02) :206-215
[100]   Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells [J].
Sturrock, A ;
Cahill, B ;
Norman, K ;
Huecksteadt, TP ;
Hill, K ;
Sanders, K ;
Karwande, SV ;
Stringham, JC ;
Bull, DA ;
Gleich, M ;
Kennedy, TP ;
Hoidal, JR .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (04) :L661-L673