Impact of cardiovascular risk factors and genetics on 10-year absolute risk of dementia: risk charts for targeted prevention

被引:49
作者
Rasmussen, Ida Juul [1 ,2 ,3 ]
Rasmussen, Katrine Laura [1 ,2 ]
Nordestgaard, Borge G. [2 ,3 ,4 ,5 ]
Tybjaerg-Hansen, Anne [1 ,2 ,3 ,5 ]
Frikke-Schmidt, Ruth [1 ,2 ,3 ]
机构
[1] Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark
[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark
[4] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark
[5] Copenhagen Univ Hosp, Bispebjerg & Frederiksberg Hosp, Copenhagen City Heart Study, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark
基金
英国医学研究理事会;
关键词
Cardiovascular risk factors; Dementia; Genetics; Epidemiology; OF-FUNCTION MUTATIONS; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; APOE GENOTYPE; INTERVENTION; POPULATION; METAANALYSIS; ASSOCIATION; PREDICTION; DECADES;
D O I
10.1093/eurheartj/ehaa695
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Dementia is a major global challenge for health and social care in aging populations. A third of all dementia may be preventable due to cardiovascular risk factors. Intensive multi-domain intervention trials targeting primarily cardiovascular risk factors show improved cognitive function in people at risk. Such interventions will, however, be expensive to implement in all individuals at risk and will represent unrealistic economic tasks for most societies. Therefore, a risk score identifying high-risk individuals is warranted. Methods and results In 61 664 individuals from two prospective cohorts of the Danish general population, we generated 10-year absolute risk scores for all-cause dementia from cardiovascular risk factors and genetics. In both sexes, 10-year absolute risk of all-cause dementia increased with increasing age, number of apotipoprotein E (APOE) epsilon 4 alleles, number of genome-wide association studies (GWAS) risk alleles, and cardiovascular risk factors. The highest 10-year absolute risks of all-cause dementia seen in smoking women with diabetes, low education, APOE epsilon 44 genotype, and 22-31 GWAS risk alleles were 6%, 23%, 48%, and 66% in those aged 50-59, 6069, 70-79, and 80-100, respectively. Corresponding values for men were 5%, 19%, 42%, and 60%, respectively. Conclusion Ten-year absolute risk of all-cause dementia increased with age, APOE epsilon 4 alleles, GWAS risk alleles, diabetes, low education, and smoking in both women and men. Ten-year absolute risk charts for dementia will facilitate identification of high-risk individuals, those who likely will benefit the most from an early intervention against cardiovascular risk factors. [GRAPHICS] .
引用
收藏
页码:4024 / +
页数:12
相关论文
共 50 条
[41]   Selenium, Selenoproteins and 10-year Cardiovascular Risk: Results from the ATTICA Study [J].
Detopoulou, Paraskevi ;
Letsiou, Sophia ;
Nomikos, Tzortzis ;
Karagiannis, Alexandros ;
Pergantis, Spiros A. ;
Pitsavos, Christos ;
Panagiotakos, Demosthenes B. ;
Antonopoulou, Smaragdi .
CURRENT VASCULAR PHARMACOLOGY, 2023, 21 (05) :346-355
[42]   Impact of cardiovascular risk factors on cognitive function: The Troms⊘ study [J].
Arntzen, K. A. ;
Schirmer, H. ;
Wilsgaard, T. ;
Mathiesen, E. B. .
EUROPEAN JOURNAL OF NEUROLOGY, 2011, 18 (05) :737-743
[43]   Disparities in neighbourhood characteristics and 10-year dementia risk by nativity status [J].
Wong, R. ;
Soong, D. .
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES, 2024, 33
[44]   Dietary B Vitamins and a 10-Year Risk of Dementia in Older Persons [J].
Lefevre-Arbogast, Sophie ;
Feart, Catherine ;
Dartigues, Jean-Francois ;
Helmer, Catherine ;
Letenneur, Luc ;
Samieri, Cecilia .
NUTRIENTS, 2016, 8 (12)
[45]   Sensorineural Impairments, Cardiovascular Risk Factors, and 10-Year Incidence of Cognitive Impairment and Decline in Midlife: The Beaver Dam Offspring Study [J].
Schubert, Carla R. ;
Cruickshanks, Karen J. ;
Fischer, Mary E. ;
Pinto, A. Alex ;
Chen, Yanjun ;
Huang, Guan-Hua ;
Klein, Barbara E. K. ;
Klein, Ronald ;
Pankow, James S. ;
Paulsen, Adam J. ;
Dalton, Dayna S. ;
Tweed, Ted S. .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2019, 74 (11) :1786-1792
[46]   Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China [J].
Tian, Ting ;
Wang, Yuanyuan ;
Xie, Wei ;
Zhang, Jingxian ;
Zhu, Qianrang ;
Peng, Xianzhen ;
Zhou, Yonglin ;
Dai, Yue .
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2021, 14 :3447-3460
[47]   Stroke Risk Factors, Genetics, and Prevention [J].
Boehme, Amelia K. ;
Esenwa, Charles ;
Elkind, Mitchell S. V. .
CIRCULATION RESEARCH, 2017, 120 (03) :472-495
[48]   Prevalence of Hypertension, Its Risk Factors and 10-year Cardiovascular Disease Risk among Bank Employees in Lagos State, Nigeria [J].
Ojo, Omobola Yetunde ;
Olasehinde, Tolulope ;
Adeniran, Adeyinka ;
Chieme, Chisom Florence ;
Aderibigbe, Adedayo Ayodele .
NIGERIAN POSTGRADUATE MEDICAL JOURNAL, 2024, 31 (03) :226-233
[49]   Follicle-Stimulating Hormone, Its Association with Cardiometabolic Risk Factors, and 10-Year Risk of Cardiovascular Disease in Postmenopausal Women [J].
Wang, Ningjian ;
Shao, Hongfang ;
Chen, Yi ;
Xia, Fangzhen ;
Chi, Chen ;
Li, Qin ;
Han, Bing ;
Teng, Yincheng ;
Lu, Yingli .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (09)
[50]   Impact of weight change, secular trends and ageing on cardiovascular risk factors: 10-year experiences from the SOS study [J].
Sjostrom, C. D. ;
Lystig, T. ;
Lindroos, A. K. .
INTERNATIONAL JOURNAL OF OBESITY, 2011, 35 (11) :1413-1420