Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development

被引：23
作者：
Imamura, T
Neildez, TMA
Thenevin, C
Paldi, A
机构：
[1] Inst Jacques Monod, INSERM E367, F-75005 Paris, France
[2] Ecole Prat Hautes Etud, F-75005 Paris, France
[3] GENETHON, F-91002 Evry, France
[4] Natl Inst Basic Biol, Dept Regulat Biol, Div Behav & Neurobiol, Okazaki 4448585, Japan
来源：
BMC MOLECULAR BIOLOGY | 2004年 / 5卷
关键词：
D O I：
10.1186/1471-2199-5-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Poly (ADP-ribosyl)ation is a covalent modification of many nuclear proteins. It has a strong chromatin modifying potential involved in DNA repair, transcription and replication. Its role during preimplantation development is unknown. Results: We have observed strong but transient synthesis of poly ADP-ribose polymers on decondensing chromosomes of fertilized and parthenogenetically activated mouse oocytes. Inhibition of this transient upregulation with a specific enzyme inhibitor, 3-aminobenzamide, has long-term effects on the postimplantation development of the embryos. In addition, inhibition of poly (ADP-ribosyl) ation at the 4-8 cell stage selectively blocks morula compaction. Conclusion: These observations suggest that poly (ADP-ribosyl) ation is involved in the epigenetic chromatin remodeling in the zygote.
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页数：11
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