Epidemiology of hypospadias in Europe: a registry-based study

被引：79

作者：

Bergman, Jorieke E. H. ^{[1
]}

Loane, Maria ^{[2
]}

Vrijheid, Martine ^{[3
,4
]}

Pierini, Anna ^{[5
]}

Nijman, Rien J. M. ^{[6
]}

Addor, Marie-Claude ^{[7
]}

Barisic, Ingeborg ^{[8
]}

Beres, Judit ^{[9
]}

Braz, Paula ^{[10
]}

Budd, Judith ^{[11
]}

Delaney, Virginia ^{[12
]}

Gatt, Miriam ^{[13
]}

Khoshnood, Babak ^{[14
]}

Klungsoyr, Kari ^{[15
,16
]}

Martos, Carmen ^{[17
]}

Mullaney, Carmel ^{[18
]}

Nelen, Vera ^{[19
]}

Neville, Amanda J. ^{[20
]}

O'Mahony, Mary ^{[21
,22
]}

Queisser-Luft, Annette ^{[23
]}

Randrianaivo, Hanitra ^{[24
]}

Rissmann, Anke ^{[25
]}

Rounding, Catherine ^{[26
]}

Tucker, David ^{[27
]}

Wellesley, Diana ^{[28
,29
]}

Zymak-Zakutnia, Natalya ^{[30
,31
]}

Bakker, Marian K. ^{[1
]}

de Walle, Hermien E. K. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[2] Univ Ulster, Inst Nursing Res, Ctr Maternal Fetal & Infant Res, EUROCAT Cent Registry, Coleraine BT52 1SA, Londonderry, North Ireland

[3] CREAL Ctr Res Environm Epidemiol, Barcelona, Spain

[4] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Barcelona, Spain

[5] CNR, Inst Clin Physiol, I-56100 Pisa, Italy

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Urol, Groningen, Netherlands

[7] Div Med Genet, Lausanne, Switzerland

[8] Univ Zagreb, Sch Med, Childrens Hosp Zagreb, Zagreb 41001, Croatia

[9] Natl Inst Hlth Dev, Dept Hungarian Congenital Abnormal Registry & Sur, Budapest, Hungary

[10] Natl Inst Hlth, Dept Epidemiol, Lisbon, Portugal

[11] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England

[12] Dr Steevens Hosp, Hlth Informat Unit, Dublin, Ireland

[13] Dept Hlth Informat & Res, Gardamangia, Malta

[14] INSERM, U953, Paris, France

[15] Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway

[16] Norwegian Inst Publ Hlth, Med Birth Registry Norway, Bergen, Norway

[17] Ctr Super Invest Salud Publ, Valencia, Spain

[18] HSE South South East, Dept Publ Hlth, South East Ireland Congenital Anomaly Registry, Kilkenny, Ireland

[19] Dept Environm, Antwerp, Belgium

[20] Univ Ferrara, Azienda Osped, IMER Registry Emilia Romagna Registry Birth Defec, I-44100 Ferrara, Italy

[21] Hlth Serv Execut South, Dept Publ Hlth, Cork, Ireland

[22] Hlth Serv Execut South, Dept Publ Hlth, Kerry, Ireland

[23] Univ Kinder Klin Mainz, Mainz, Germany

[24] CHU Reunion, Unit Congenital Malformat & Med Genet, St Pierre, France

[25] Univ Magdeburg, Fac Med, Malformat Monitoring Ctr Saxony Anhalt, D-39106 Magdeburg, Germany

[26] Univ Oxford, Natl Perinatal Epidemiol Unit, Oxford, England

[27] Singleton Hosp, Congenital Anomaly Register & Informat Serv Publ, Swansea, W Glam, Wales

[28] Southampton Univ Hosp, Fac Med, Southampton, Hants, England

[29] Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England

[30] OMNI Net Ukraine, Khmelnytsky, Ukraine

[31] Khmelnytsky Perinatal Ctr, Khmelnytsky, Ukraine

来源：

WORLD JOURNAL OF UROLOGY | 2015年 / 33卷 / 12期

关键词：

Ascertainment; Congenital anomaly registers; Epidemiology; Hypospadias; Maternal age; Prevalence; MATERNAL AGE; CONGENITAL-MALFORMATIONS; EXTERNAL GENITALIA; RISK-FACTOR; TRENDS; PREVALENCE; ANOMALIES; CRYPTORCHIDISM; POPULATION; ETIOLOGY;

D O I：

10.1007/s00345-015-1507-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hypospadias is a common congenital malformation. The prevalence of hypospadias has a large geographical variation, and recent studies have reported both increasing and decreasing temporal trends. It is unclear whether hypospadias prevalence is associated with maternal age. To analyze the prevalence and trends of total hypospadias, isolated hypospadias, hypospadias with multiple congenital anomalies, hypospadias with a known cause, and hypospadias severity subtypes in Europe over a 10-year period and to investigate whether maternal age is associated with hypospadias. We included all children with hypospadias born from 2001 to 2010 who were registered in 23 EUROCAT registries. Information on the total number of births and maternal age distribution for the registry population was also provided. We analyzed the total prevalence of hypospadias and relative risks by maternal age. From 2001 to 2010, 10,929 hypospadias cases were registered in 5,871,855 births, yielding a total prevalence of 18.61 per 10,000 births. Prevalence varied considerably between different registries, probably due to differences in ascertainment of hypospadias cases. No significant temporal trends were observed with the exceptions of an increasing trend for anterior and posterior hypospadias and a decreasing trend for unspecified hypospadias. After adjusting for registry effects, maternal age was not significantly associated with hypospadias. Total hypospadias prevalence was stable in 23 EUROCAT registries from 2001 to 2010 and was not significantly influenced by maternal age.

引用

页码：2159 / 2167

页数：9

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