Fc receptors for IgG and antigen presentation on MHC class I and class II molecules

被引:64
作者
Amigorena, S [1 ]
Bonnerot, C [1 ]
机构
[1] Inst Curie, INSERM, U520, F-75005 Paris, France
关键词
antigen presentation; B lymphocytes; dendritic cells; Fc receptors; immune complexes;
D O I
10.1006/smim.1999.0196
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigens internalized through specific membrane receptors are presented to helper CD4+ T cells antigen concentrations 10(3) to 10(4) fold lower than antigens internalized by fluid phase. B lymphocyte antigen receptors, mannose receptors and receptors for the Fc region of immunoglobulins promote both internalization and immunoglobulins, low antigen concentration. Thus, binding to specific membrane receptors concentrate antigens on antigen presenting cells and mediates efficient uptake. Is this 'quantitative' concentration of antigens on antigen presenting cells the end of the story? Or may 'quality', i.e. selective intracellular antigen targeting, somehow influence the efficiency or specificity of MHC class I and class II-restricted antigen presentation?
引用
收藏
页码:385 / 390
页数:6
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