Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder

被引：43

作者：

Brandl, E. J. ^{[1
,2
]}

Tiwari, A. K. ^{[1
,2
]}

Zhou, X. ^{[2
,3
]}

Deluce, J. ^{[2
,3
]}

Kennedy, J. L. ^{[1
,2
]}

Mueller, D. J. ^{[1
,2
]}

Richter, M. A. ^{[1
,2
,3
]}

机构：

[1] Ctr Addict & Mental Hlth, Dept Neurosci, Neurogenet Sect, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[3] Sunnybrook Hlth Sci Ctr, Dept Psychiat, Toronto, ON M4N 3M5, Canada

来源：

PHARMACOGENOMICS JOURNAL | 2014年 / 14卷 / 02期

关键词：

obsessive-compulsive disorder (OCD); pharmacogenetics; CYP2D6; CYP2C19; treatment response; EVIDENCE-BASED PHARMACOTHERAPY; SEROTONIN REUPTAKE INHIBITORS; JAPANESE PSYCHIATRIC-PATIENTS; CYTOCHROME-P450; 2D6; GENOTYPE; STAR-ASTERISK-D; PLASMA-CONCENTRATIONS; DEPRESSED-PATIENTS; THERAPEUTIC RESPONSE; CLINICAL-RESPONSE; ACTIVITY SCORE;

D O I：

10.1038/tpj.2013.12

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40-60%). Our study is the largest investigation to date (N= 184) of treatment response and side effects to antidepressants in OCD based on metabolizer status for CYP2D6 and CYP2C19. We observed significantly more failed medication trials in CYP2D6 non-extensive compared with extensive metabolizers (P= 0.007). CYP2D6 metabolizer status was associated with side effects to venlafaxine (P= 0.022). There were nonsignificant trends for association of CYP2D6 metabolizer status with response to fluoxetine (P= 0.056) and of CYP2C19 metabolizer status with response to sertraline (P= 0.064). Our study is the first to indicate that CYP genes may have a role in antidepressant response in OCD. More research is required for a future clinical application of genetic testing, which could lead to improved treatment outcomes.

引用

页码：176 / 181

页数：6

共 72 条

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