Immunohistochemical Biomarkers of Survival in Patients With Adenocarcinoma of the Uterine Cervix Receiving Chemoradiotherapy

被引：4

作者：

Lin, Ying-Chun ^{[1
]}

Chen, Rui-Yun ^{[2
]}

Liang, Ji-An ^{[1
,3
]}

Hung, Yao-Ching ^{[3
,4
]}

Yeh, Lian-Shung ^{[3
,4
]}

Chang, Wei-Chun ^{[3
,4
]}

Lin, Wu-Chou ^{[4
,5
]}

Chang, Yin-Yi ^{[4
,5
]}

Chen, Shang-Wen ^{[1
,3
,6
]}

机构：

[1] China Med Univ Hosp, Dept Radiat Oncol, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Radiat Oncol, Taichung, Taiwan

[3] China Med Univ, Grad Inst Clin Med Sci, Sch Med, Coll Med, Taichung, Taiwan

[4] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan

[5] China Med Univ, Sch Chinese Med, Coll Med, Taichung, Taiwan

[6] Taipei Med Univ, Sch Med, Dept Radiol, Coll Med, Taipei, Taiwan

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 06期

关键词：

Cervical adenocarcinoma; chemoradiotherapy; immunohistochemistry; prognosis; myeloid cell leukemia-1; SQUAMOUS-CELL CARCINOMA; C-MYC; HUMAN-PAPILLOMAVIRUS; PROGNOSTIC-FACTORS; UNITED-STATES; UP-REGULATION; STAGE IB; CANCER; RADIATION; RADIOTHERAPY;

D O I：

10.21873/anticanres.13464

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: To determine the prognostic effects of immunohistochemical biomarkers for predicting chemoradiotherapy (CRT)-based treatment outcomes in patients with adenocarcinoma of the uterine cervix. Materials and Methods: This study included 42 patients receiving definitive CRT. According to the International Federation of Gynecology and Obstetrics staging system, 13, 21, and 8 patients were classified as having stage IB2, II, and III disease, respectively. Baseline immunohistochemical biomarkers, including those for hypoxia, cell proliferation, cell adhesion, immunogenicity, and evasion of apoptosis, were analyzed using tissue microarrays from biopsy specimens. Results: Myeloid cell leukemia-1 (MCL1) overexpression and the presence of pelvic lymph node metastasis were two prognostic factors for inferior cancer-specific survival. A higher H-score for c-MYC proto-oncogene, bHLH transcription factor (c-MYC) was associated with lower pelvic relapse-free survival. Conclusion: For patients with adenocarcinoma of the uterine cervix requiring definitive CRT, treatment outcomes can be stratified by the immunohistochemical biomarkers MCL1 and c-MYC for cancer death and local failure, respectively.

引用

页码：3231 / 3240

页数：10

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