In search of a new paradigm for protective immunity to TB

被引：218
作者：
Nunes-Alves, Cludio [1 ,2 ,3 ]
Booty, Matthew G. [1 ,4 ]
Carpenter, Stephen M. [1 ,5 ]
Jayaraman, Pushpa [1 ]
Rothchild, Alissa C. [1 ,4 ]
Behar, Samuel M. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA 01655 USA
[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
[3] ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga, Portugal
[4] Harvard Univ, Sch Med, Div Med Sci, Program Immunol, Boston, MA 02115 USA
[5] Brigham & Womens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2014年 / 12卷 / 04期
关键词：
MYCOBACTERIUM-TUBERCULOSIS INFECTION; CALMETTE-GUERIN VACCINATION; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; HUMAN ALVEOLAR MACROPHAGES; IFN-GAMMA; INTERFERON-GAMMA; CELL RESPONSES; LATENT TUBERCULOSIS; VITAMIN-D;
D O I：
10.1038/nrmicro3230
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and results are starting to come in. Some of these results are not so encouraging, as exemplified by the latest Aeras-422 and MVA85A trials. Other than empirically determining whether a vaccine reduces the number of cases of active tuberculosis, which is a daunting prospect given the chronic nature of the disease, we have no way of assessing vaccine efficacy. Therefore, investigators seek to identify biomarkers that predict vaccine efficacy. Historically, focus has been on the production of interferon-gamma by CD4(+) T cells, but this has not been a useful correlate of vaccine-induced protection. In this Opinion article, we discuss recent advances in our understanding of the immune control of M. tuberculosis and how this knowledge could be used for vaccine design and evaluation.
引用
收藏
页码：289 / 299
页数：11
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