Population Screening for Hereditary Colorectal Cancer

被引：19

作者：

Hampel, Heather ^{[1
]}

机构：

[1] Ohio State Univ, Div Human Genet, Dept Internal Med, Comprehens Canc Ctr, 2012 Kenny Rd,Room 257, Columbus, OH 43221 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 27卷 / 02期

关键词：

Lynch syndrome; Cancer genetics; Hereditary; Colon cancer; Screening; NEWLY-DIAGNOSED PATIENTS; LYNCH-SYNDROME; TESTING STRATEGIES; COST-EFFECTIVENESS; MANAGEMENT; MUTATIONS; TUMORS;

D O I：

10.1016/j.soc.2017.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer can be caused by hereditary cancer syndromes such as Lynch syndrome and the polyposis syndromes. Tumor screening for Lynch syndrome has been recommended by several professional organizations. In addition, it has been shown that patients with microsatellite unstable colorectal cancer can benefit from immunotherapy. Unfortunately, universal tumor screening for Lynch syndrome has not been implemented at all hospitals yet. More recent studies have found that the prevalence of all hereditary cancer syndromes is around 10%, and for those diagnosed under age 50 years, it is closer to 16%. It may be time to consider offering genetic counseling and testing to all patients with colorectal cancer.

引用

页码：319 / +

页数：8

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