The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

被引：308

作者：

Balda, MS ^{[1
]}

Matter, K ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

来源：

EMBO JOURNAL | 2000年 / 19卷 / 09期

关键词：

epithelia; MAGUK; tight junctions; Y-box; ZONAB;

D O I：

10.1093/emboj/19.9.2024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical and basolateral plasma membrane components. We now identify a Y-bos transcription factor, ZONAB (<(ZO)under bar>-1-associated nucleic acid-binding protein), that binds to the SH3 domain of ZO-1, a submembrane protein of tight junctions. ZONAB localizes to the nucleus and at tight junctions, and binds to sequences of specific promoters containing an inverted CCAAT hox. In reporter assays, ZONAB and ZO-1 functionally interact in the regulation of the ErbB-2 promoter in a cell density-dependent manner. In stably transfected over-expressing cells, ZO-1 and ZONAB control expression of endogenous ErbB-2 and function in the regulation of paracellular permeability. These data indicate that tight junctions directly participate in the control of gene expression and suggest that they function in the regulation of epithelial cell differentiation.

引用

页码：2024 / 2033

页数：10

共 37 条

[31] Transforming growth factor-β signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain [J].

Ronaldson, Patrick T. ;

DeMarco, Kristin M. ;

Sanchez-Covarrubias, Lucy ;

Solinsky, Christine M. ;

Davis, Thomas P. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 (06) :1084-1098

[32] Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome [J].

Bertrand, Julien ;

Ghouzali, Ibtissem ;

Guerin, Charlene ;

Bole-Feysot, Christine ;

Gouteux, Melodie ;

Dechelotte, Pierre ;

Ducrotte, Philippe ;

Coeffier, Moise .

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2016, 40 (08) :1170-1176

[33] The expression patterns of tight junction protein claudin-1,-3, and-4 in human gastric neoplasms and adjacent non-neoplastic tissues [J].

Wang, Haiming ;

Yang, Xingwang .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (01) :881-887

[34] Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier:: role of myosin light-chain kinase protein expression [J].

Ma, TY ;

Boivin, MA ;

Ye, DM ;

Pedram, A ;

Said, HM .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (03) :G422-G430

[35] β(2 → 1)-β(2 → 6) and β(2 → 1) fructans protect from impairment of intestinal tight junction's gene expression and attenuate human dendritic cell responses in a fructan-dependent fashion [J].

Fernandez-Lainez, Cynthia ;

aan de Stegge, Myrthe ;

Silva-Lagos, Luis Alfredo ;

Lopez-Velazquez, Gabriel ;

de Vos, Paul .

CARBOHYDRATE POLYMERS, 2023, 320

[36] Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis [J].

De Maio, Flavio ;

Lo Cascio, Ettore ;

Babini, Gabriele ;

Sali, Michela ;

Della Longa, Stefano ;

Tilocca, Bruno ;

Roncada, Paola ;

Arcovito, Alessandro ;

Sanguinetti, Maurizio ;

Scambia, Giovanni ;

Urbani, Andrea .

MICROBES AND INFECTION, 2020, 22 (10) :592-597

[37] Effect of a two-week treatment with a low dose of 2,2′4,4′,5,5′-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods [J].

Szczepkowska, Aleksandra ;

Lagaraine, Christine ;

Robert, Vincent ;

Dufourny, Laurence ;

Thiery, Jean-Claude ;

Skipor, Janina .

NEUROTOXICOLOGY AND TERATOLOGY, 2013, 37 :63-67

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