The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

被引:306
作者
Balda, MS [1 ]
Matter, K [1 ]
机构
[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
关键词
epithelia; MAGUK; tight junctions; Y-box; ZONAB;
D O I
10.1093/emboj/19.9.2024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical and basolateral plasma membrane components. We now identify a Y-bos transcription factor, ZONAB (<(ZO)under bar>-1-associated nucleic acid-binding protein), that binds to the SH3 domain of ZO-1, a submembrane protein of tight junctions. ZONAB localizes to the nucleus and at tight junctions, and binds to sequences of specific promoters containing an inverted CCAAT hox. In reporter assays, ZONAB and ZO-1 functionally interact in the regulation of the ErbB-2 promoter in a cell density-dependent manner. In stably transfected over-expressing cells, ZO-1 and ZONAB control expression of endogenous ErbB-2 and function in the regulation of paracellular permeability. These data indicate that tight junctions directly participate in the control of gene expression and suggest that they function in the regulation of epithelial cell differentiation.
引用
收藏
页码:2024 / 2033
页数:10
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