Automated high-throughput cell microsurgery on-chip

被引：50

作者：

Chung, Kwanghun ^{[1
]}

Lu, Hang ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

来源：

LAB ON A CHIP | 2009年 / 9卷 / 19期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

C-ELEGANS; CAENORHABDITIS-ELEGANS; NEURONS; IMMOBILIZATION;

D O I：

10.1039/b910703g

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Laser cell kill is an established tool for studying cells' roles during development and behavior, but its use has been limited due to the manual and low-throughput nature. We demonstrate here a technique combining multiplexing microfluidic manipulation of Caenorhabditis elegans and software for image processing and automation, allowing for high-throughput cell ablations.

引用

页码：2764 / 2766

页数：3

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