Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

被引：132
作者：
Shao, Anwen [1 ]
Tu, Sheng [2 ]
Lu, Jianan [1 ]
Zhang, Jianmin [1 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, Dept Infect Dis,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
[3] Zhejiang Univ, Brain Res Inst, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Univ, Collaborat Innovat Ctr Brain Sci, Hangzhou 310003, Zhejiang, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2019年 / 10卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Spinal cord injury; Stem cell; Mechanism; Therapy; Review; MESENCHYMAL STROMAL CELLS; NEURAL PRECURSOR CELLS; HUMAN BONE-MARROW; FUNCTIONAL RECOVERY; RAT MODEL; IN-VITRO; DIRECTED DIFFERENTIATION; AMNIOTIC MEMBRANE; OXIDATIVE STRESS; AXONAL GROWTH;
D O I：
10.1186/s13287-019-1357-z
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.
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页数：13
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