Patients with cystic fibrosis have a high carriage rate of non-toxigenic Clostridium difficile

被引：19

作者：

Bauer, M. P. ^{[1
]}

Farid, A. ^{[1
]}

Bakker, M. ^{[2
]}

Hoek, R. A. S. ^{[2
]}

Kuijper, E. J. ^{[3
]}

van Dissel, J. T. ^{[1
]}

机构：

[1] Leiden Univ Med Ctr, Dept Infect Dis, Ctr Infect Dis, Leiden, Netherlands

[2] Erasmus MC, Dept Pulmonol, Rotterdam, Netherlands

[3] Leiden Univ Med Ctr, Dept Med Microbiol, Ctr Infect Dis, Leiden, Netherlands

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 07期

关键词：

Asymptomatic carriage; CFTR mutations; Clostridium difficile; cystic fibrosis; PCR ribotypes; TOXIN; PCR;

D O I：

10.1111/1469-0691.12439

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Thirty-year-old observations report frequent asymptomatic Clostridium difficile carriage among cystic fibrosis (CF) patients. In this case-control study, we found more carriers among CF patients than controls (47% versus 11%), but most strains carried by CF patients were non-toxigenic (77% versus 17%). Among CF patients, carriers were younger, with more severe pulmonary disease than non-carriers. Strains belonged to multiple PCR-ribotypes, suggesting that these CF patients did not acquire strains from each other.

引用

页码：O446 / O449

页数：4

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