A regulatory role for complement in innate immunity and autoimmunity

被引：51
作者：
Nauta, AJ [1 ]
Roos, A [1 ]
Daha, MR [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2333 ZA Leiden, Netherlands
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2004年 / 134卷 / 04期
关键词：
complement; apoptosis; autoimmunity; receptors; dendritic cells;
D O I：
10.1159/000079261
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The complement system comprises a strong defense against various pathogens and is a major component of our innate immune system. While earlier studies have established a crucial role of complement in recognition, opsonization and enhanced phagocytosis of microorganisms by professional phagocytes such as polymorphonuclear leukocytes and macrophages, recent studies delineate an additional role of complement in initiation and maintenance of the acquired immune response. In addition, it seems that opsonization of apoptotic cells by complement may lead to polarization of the response of professional antigen-presenting cells to a more inflammatory or tolerogenic response. The present review summarizes these different contributions of complement to the shaping of the immune balance. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码：310 / 323
页数：14
相关论文
共 149 条
  • [1] Transgenic mice expressing rabbit C-Reactive protein exhibit diminished chemotactic factor-induced alveolitis
    Ahmed, N
    Thorley, R
    Xia, DY
    Samols, D
    Webster, RO
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (03) : 1141 - 1147
  • [2] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs
    Albert, ML
    Sauter, B
    Bhardwaj, N
    [J]. NATURE, 1998, 392 (6671) : 86 - 89
  • [3] ALBERTI S, 1993, INFECT IMMUN, V61, P852
  • [4] ALLES VV, 1994, BLOOD, V84, P3483
  • [5] Therapeutic inhibition of the complement system. Y2K update
    Asghar, SS
    Pasch, MC
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2000, 5 : E63 - E82A
  • [6] INDUCTION OF INFLAMMATORY CYTOKINE RELEASE FROM CULTURED HUMAN MONOCYTES BY C-REACTIVE PROTEIN
    BALLOU, SP
    LOZANSKI, G
    [J]. CYTOKINE, 1992, 4 (05) : 361 - 368
  • [7] BALTZ ML, 1986, CLIN EXP IMMUNOL, V66, P691
  • [8] The role of complement in inflammation and adaptive immunity
    Barrington, R
    Zhang, M
    Fischer, M
    Carroll, MC
    [J]. IMMUNOLOGICAL REVIEWS, 2001, 180 : 5 - 15
  • [9] THE ACUTE-PHASE RESPONSE
    BAUMANN, H
    GAULDIE, J
    [J]. IMMUNOLOGY TODAY, 1994, 15 (02): : 74 - 80
  • [10] CELL-DEATH IN HEALTH AND DISEASE - THE BIOLOGY AND REGULATION OF APOPTOSIS
    BELLAMY, COC
    MALCOMSON, RDG
    HARRISON, DJ
    WYLLIE, AH
    [J]. SEMINARS IN CANCER BIOLOGY, 1995, 6 (01) : 3 - 16
12345678910