Regulation of iron homeostasis: Lessons from mouse models

被引：27

作者：

Altamura, Sandro ^{[1
,2
]}

Marques, Oriana ^{[1
,2
]}

Colucci, Silvia ^{[1
,2
]}

Mertens, Christina ^{[1
]}

Alikhanyan, Kristina ^{[1
]}

Muckenthaler, Martina U. ^{[1
,2
,3
,4
]}

机构：

[1] Heidelberg Univ, Dept Pediat Hematol Oncol & Immunol, INF 350, D-69120 Heidelberg, Germany

[2] Mol Med Partnership Unit, Heidelberg, Germany

[3] German Ctr Lung Res DZL, Translat Lung Res Ctr TLRC, Heidelberg, Germany

[4] DZHK German Ctr Cardiovasc Res, Partner Site Heidelberg Mannheim, Heidelberg, Germany

来源：

MOLECULAR ASPECTS OF MEDICINE | 2020年 / 75卷

关键词：

TRANSFERRIN RECEPTOR 2; HEPCIDIN GENE-EXPRESSION; HEME EXPORTER; TARGETED DISRUPTION; MICROCYTIC ANEMIA; MICE LACKING; MURINE MODELS; H-FERRITIN; NULL MICE; OVERLOAD;

D O I：

10.1016/j.mam.2020.100872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is an essential micronutrient and a critical cofactor for proteins involved in fundamental processes such as oxygen transport, energy production and DNA synthesis. However, iron levels need to be tightly balanced to avoid pathological consequences of iron overload or deficiency. Genetically engineered mouse models with alterations in systemic or cellular iron handling advanced our knowledge how systemic and cellular iron homeostasis is maintained. Here, we prepared a comprehensive overview of mouse models that provide insight into mechanisms of iron regulation and/or rare or frequent iron-related disorders.

引用

页数：20

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