Matrix metalloproteinase genes in Xenopus development

被引:54
作者
Harrison, M [1 ]
Abu-Elmagd, M [1 ]
Grocott, T [1 ]
Yates, C [1 ]
Gavrilovic, J [1 ]
Wheeler, GN [1 ]
机构
[1] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England
关键词
matrix metalloproteinases; MMP-14; MMP-15; MMP-7; MMP24; development; Xenopus laevis; macrophage; myeloid; ventral blood island; hindbrain; rhombomeres; neural crest;
D O I
10.1002/dvdy.20113
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages; or other myeloid cell types from early in development. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:214 / 220
页数:7
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