Matrix metalloproteinase genes in Xenopus development

被引：54

作者：

Harrison, M ^{[1
]}

Abu-Elmagd, M ^{[1
]}

Grocott, T ^{[1
]}

Yates, C ^{[1
]}

Gavrilovic, J ^{[1
]}

Wheeler, GN ^{[1
]}

机构：

[1] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

DEVELOPMENTAL DYNAMICS | 2004年 / 231卷 / 01期

关键词：

matrix metalloproteinases; MMP-14; MMP-15; MMP-7; MMP24; development; Xenopus laevis; macrophage; myeloid; ventral blood island; hindbrain; rhombomeres; neural crest;

D O I：

10.1002/dvdy.20113

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages; or other myeloid cell types from early in development. (C) 2004 Wiley-Liss, Inc.

引用

页码：214 / 220

页数：7

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