Immune check-point in endometrial cancer

被引：35
|
作者：
De Felice, Francesca [1 ]
Marchetti, Claudia [2 ]
Tombolini, Vincenzo [1 ]
Panici, P. Benedetti [3 ]
机构：
[1] Sapienza Univ Rome, Policlin Umberto 1, Dept Radiotherapy, Viale Regina Elena 326, I-00161 Rome, Italy
[2] Fdn Policlin Univ A Gemelli IRCCS, Div Gynecol Oncol, Rome, Italy
[3] Sapienza Univ Rome, Dept Gynecol Obstet Sci & Urol Sci, Rome, Italy
来源：
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2019年 / 24卷 / 08期
关键词：
Endometrial cancer; Immunotherapy; Immune check-point; Survival; Microsatellite instability; Mismatch repair; MISMATCH REPAIR STATUS; WOMEN; BLOCKADE; TUMORS; PEMBROLIZUMAB; ASSOCIATION; CARCINOMAS; EXPRESSION; OUTCOMES; PD-1;
D O I：
10.1007/s10147-019-01437-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Endometrial cancer (EC) is one of the most frequent tumors in women. Despite recent advances in treatment approaches, the prognosis in advanced, recurrent, or metastatic disease remains poor. The aim was to provide the clinician with an update, the current status, and the new developments in the management of EC. Based on the new EC molecular classification, we focused on the impact of immune check-point inhibitors. Methods Pivotal trials, published literature, and conference proceedings were reviewed. PubMed and Scopus databases were searched to select English-language articles. Results Immune check-point inhibitors are the subject of ongoing studies and their benefit seems to be related to microsatellite instability (MSI) status. Conclusions Immune check-point inhibitors should be considered a promising treatment option to better personalize therapeutic strategies in EC.
引用
收藏
页码：910 / 916
页数：7
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