Circadian transcription factor BMAL1 regulates innate immunity against select RNA viruses

被引：58
作者：
Majumdar, Tanmay
Dhar, Jayeeta
Patel, Sonal
Kondratov, Roman
Barik, Sailen [1 ]
机构：
[1] Cleveland State Univ, Dept Biol Geol & Environm Sci, 2121 Euclid Ave, Cleveland, OH 44115 USA
来源：
INNATE IMMUNITY | 2017年 / 23卷 / 02期
关键词：
BMAL1; circadian clock; innate immunity; parainfluenza virus; Paramyxovirus; pneumovirus; respiratory syncytial virus; Toxoplasma gondii; RESPIRATORY SYNCYTIAL VIRUS; VESICULAR STOMATITIS-VIRUS; PROTEIN CLOCK; A549; CELLS; SUBGROUP-B; INFECTION; IDENTIFICATION; DEFICIENCY; INHIBITION; EXPRESSION;
D O I：
10.1177/1753425916681075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
BMAL1 (brain and muscle ARNT-like protein 1, also known as MOP3 or ARNT3) belongs to the family of the basic helix-loop-helix (bHLH)-PAS domain-containing transcription factors, and is a key component of the molecular oscillator that generates circadian rhythms. Here, we report that BMAL1-deficient cells are significantly more susceptible to infection by two major respiratory viruses of the Paramyxoviridae family, namely RSV and PIV3. Embryonic fibroblasts from Bmal1(-/-) mice produced nearly 10-fold more progeny virus than their wild type controls. These results were supported by animal studies whereby pulmonary infection of RSV produced a more severe disease and morbidity in Bmal1(-/-) mice. These results show that BMAL1 can regulate cellular innate immunity against specific RNA viruses.
引用
收藏
页码：147 / 154
页数：8
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