Organocatalysis in Enantioselective α-Functionalization of 2-Cyanoacetates

被引：24

作者：

Diaz-de-Villegas, Maria D. ^{[1
]}

Galvez, Jose A. ^{[1
]}

Badorrey, Ramon ^{[1
]}

Lopez-Ram-de-Viu, Pilar ^{[1
]}

机构：

[1] Univ Zaragoza, CSIC, ISQCH, Dept Catalisis & Proc Catalit, E-50009 Zaragoza, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 16期

关键词：

cyanides; cyano esters; enantioselectivity; organic catalysis; synthetic methods; ASYMMETRIC CONJUGATE ADDITION; PINCER PALLADIUM COMPLEXES; PHASE-TRANSFER; SUBSTITUTED CYANOACETATES; MICHAEL ADDITION; MULTICOMPONENT REACTIONS; ALLYLIC ALKYLATION; ALPHA; BETA-UNSATURATED IMIDES; STEREOSELECTIVE AMINATION; QUATERNARY STEREOCENTERS;

D O I：

10.1002/adsc.201400404

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Recent progress in asymmetric organocatalysis has led to the development of several asymmetric transformations that employ various substrates. Among these, cyanoacetates have emerged as excellent nucleophiles in conjugate addition, alkylation, Mannich and alpha-heterofunctionalization reactions. In this review we discuss the enantioselective functionalization of 2-cyanoacetates through organocatalytic reactions.

引用

页码：3261 / 3288

页数：28

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