Coordinating gene expression during the cell cycle

被引：127

作者：

Fischer, Martin ^{[1
]}

Schade, Amy E. ^{[2
,3
]}

Branigan, Timothy B. ^{[3
,4
,5
]}

Mueller, Gerd A. ^{[6
]}

DeCaprio, James A. ^{[3
,4
,5
]}

机构：

[1] FLI, Computat Biol Grp, Leibniz Inst Aging, D-07745 Jena, Germany

[2] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[5] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[6] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2022年 / 47卷 / 12期

关键词：

S-M CHECKPOINT; DREAM COMPLEX; TRANSCRIPTION FACTOR; PROTEIN COMPLEX; REPRESS TRANSCRIPTION; MOLECULAR-MECHANISMS; REPLICATION STRESS; TUMOR-SUPPRESSOR; MUVB COMPLEX; B-MYB;

D O I：

10.1016/j.tibs.2022.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for DNA synthesis. The second set, with maximum expression during G2/M, is required for mitosis and is coordinated by the MuvB complex, together with B-MYB and Forkhead box M1 (FOXM1). In this review, we summarize the key findings that established the distinct control mechanisms regulating G1/S and G2/M gene expression in mammals and discuss recent advances in the understanding of the temporal control of these genes.

引用

页码：1009 / 1022

页数：14

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