Gut-Brain Cross-Talk in Metabolic Control

被引：228

作者：

Clemmensen, Christoffer ^{[1
,2
,3
]}

Mueller, Timo D. ^{[1
,2
,3
]}

Woods, Stephen C. ^{[4
]}

Berthoud, Hans-Rudolf ^{[5
]}

Seeley, Randy J. ^{[6
,7
,8
]}

Tschoep, Matthias H. ^{[1
,2
,3
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Inst Diabet & Obes, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany

[2] German Res Ctr Environm Hlth GmbH, German Ctr Diabet Res DZD, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany

[3] Tech Univ Munich, Dept Med, Div Metab Dis, D-80333 Munich, Germany

[4] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45220 USA

[5] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70803 USA

[6] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Nutr Sci, Ann Arbor, MI 48109 USA

来源：

CELL | 2017年 / 168卷 / 05期

基金：

欧洲研究理事会;

关键词：

GLUCAGON-LIKE PEPTIDE-1; Y GASTRIC BYPASS; VERTICAL SLEEVE GASTRECTOMY; INTRAGANGLIONIC LAMINAR ENDINGS; RESTING ENERGY-EXPENDITURE; SERUM BILE-ACIDS; BODY-MASS INDEX; MELANOCORTIN-4; RECEPTOR; FOOD-INTAKE; WEIGHT-LOSS;

D O I：

10.1016/j.cell.2017.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.

引用

页码：758 / 774

页数：17

共 201 条

[1] Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite [J].

Abizaid, Alfonso ;

Liu, Zhong-Wu ;

Andrews, Zane B. ;

Shanabrough, Marya ;

Borok, Erzsebet ;

Elsworth, John D. ;

Roth, Robert H. ;

Sleeman, Mark W. ;

Picciotto, Marina R. ;

Tschop, Matthias H. ;

Gao, Xiao-Bing ;

Horvath, Tamas L. .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) :3229-3239

[2] GLP-1 and energy balance: an integrated model of short-term and long-term control [J].

Barrera, Jason G. ;

Sandoval, Darleen A. ;

D'Alessio, David A. ;

Seeley, Randy J. .

NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (09) :507-516

[3] PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans [J].

Batterham, Rachel L. ;

ffytche, Dominic H. ;

Rosenthal, J. Miranda ;

Zelaya, Fernando O. ;

Barker, Gareth J. ;

Withers, Dominic J. ;

Williams, Steven C. R. .

NATURE, 2007, 450 (7166) :106-+

[4] Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes [J].

Baxter, John D. ;

Webb, Paul .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (04) :308-320

[5] Vagal and hormonal gut-brain communication: from satiation to satisfaction [J].

Berthoud, H. -R. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2008, 20 :64-72

[6] The vagus nerve, food intake and obesity [J].

Berthoud, Hans-Rudolf .

REGULATORY PEPTIDES, 2008, 149 (1-3) :15-25

[7] The brain, appetite, and obesity [J].

Berthoud, Hans-Rudolf ;

Morrison, Christopher .

ANNUAL REVIEW OF PSYCHOLOGY, 2008, 59 :55-92

[8]

Berthoud HR, 1996, ACTA ANAT, V156, P123

[9]

BERTHOUD HR, 1995, ANAT EMBRYOL, V191, P203

[10] Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract [J].

Berthoud, HR ;

Patterson, LM ;

Neumann, F ;

Neuhuber, WL .

ANATOMY AND EMBRYOLOGY, 1997, 195 (02) :183-191

← 1 2 3 4 5 6 7 8 9 10 →