Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

被引：2

作者：

Jiang, Yi ^{[1
]}

Xu, Hong ^{[1
]}

Liu, Li ^{[1
]}

He, Rui ^{[1
]}

Song, Xiaomei ^{[1
]}

Li, Na ^{[1
]}

机构：

[1] Shaanxi Univ Chinese Med, Xianyang 712046, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 06期

关键词：

Cancer; Drug design; Anti-cancer activity; Aryl benzyl ethers; Fluoro substituents; Structure-activity relationship; NATURAL-PRODUCTS; DERIVATIVES; INHIBITORS; DISCOVERY; COUMARIN; ANALOGS; DESIGN; POTENT;

D O I：

10.2174/1570180811666140130232233

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.

引用

页码：736 / 741

页数：6

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