Semiquantitative and Quantitative Analyses of Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Thyroid Nodules

被引:21
作者
Ben-David, Eliel [1 ]
Sadeghi, Nader [2 ]
Rezaei, M. Katayoon [3 ]
Muradyan, Naira [4 ]
Brown, Derek [5 ]
Joshi, Arjun [2 ]
Taheri, M. Reza [1 ]
机构
[1] George Washington Univ, Med Ctr, Dept Radiol, Washington, DC 20037 USA
[2] George Washington Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Washington, DC 20037 USA
[3] George Washington Univ, Med Ctr, Dept Pathol, Washington, DC 20037 USA
[4] iCAD Inc, Nashua, NH USA
[5] George Washington Univ, Dept Epidemiol & Biostat, Washington, DC USA
关键词
thyroid; preoperative workup; thyroid nodule evaluation; dynamic contrast enhancement MRI; semiquantitative analysis; quantitative analysis; ENDOTHELIAL GROWTH-FACTOR; DIAGNOSTIC-VALUE; FACTOR EXPRESSION; MRI; BENIGN; TUMORS; PERMEABILITY; CANCER;
D O I
10.1097/RCT.0000000000000304
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective This study was aimed to determine the utility of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) in differentiating benign and malignant lesions in patients with known thyroid gland lesions scheduled for resection. Methods Patients scheduled for resection of a thyroid mass were prospectively enrolled. Dynamic contrast-enhanced MRI scans of the neck were performed before surgery. After resection, patients were divided into benign and malignant groups. Quantitative and semiquantitative MRI kinetic measurements of benign and malignant lesions were compared and analyzed. Results Twelve benign and 9 malignant lesions were identified in 19 patients. Mean K-trans, V-e, and K-ep for benign lesions were 1.69 1.59 min(-1), 0.44 +/- 0.21 min(-1), and 4.51 +/- 2.96 min(-1), respectively; for the malignant lesions, 0.96 +/- 0.57 min(-1), 0.45 +/- 0.19 min(-1), and 3.57 +/- 3.53 min(-1), respectively (P = 0.1886, 0.8036, and 0.3028, respectively). T-peak, ERmax, slope(max), and iAUGC60 for benign lesions were 7.00 +/- 8.09 seconds, 293.27 +/- 141.25 seconds, 76.45 +/- 65.80 seconds, and 63.46 +/- 46.84, respectively; for malignant lesions, 8.11 +/- 8.55 seconds, 227.6 +/- 113.37 seconds, 81.17 +/- 109.71 seconds, and 43.69 +/- 26.19, respectively (P = 0.7525, 0.4941, 0.4474, and 0.3028, respectively). Conclusions Dynamic contrast-enhanced MRI pattern of kinetics was not significantly different for benign and malignant lesions of the thyroid using quantitative or semiquantitative methods.
引用
收藏
页码:855 / 859
页数:5
相关论文
共 30 条
[1]   Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI [J].
Asaumi, J ;
Hisatomi, M ;
Yanagi, Y ;
Matsuzaki, H ;
Choi, YS ;
Kawai, N ;
Konouchi, H ;
Kishi, K .
EUROPEAN JOURNAL OF RADIOLOGY, 2005, 56 (01) :25-30
[2]   Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: initial results [J].
Bartolotta, Tommaso Vincenzo ;
Midiri, Massimo ;
Galia, Massimo ;
Runza, Giuseppe ;
Attard, Marco ;
Savoia, Giovanni ;
Lagalla, Roberto ;
Cardinale, Adelfio Elio .
EUROPEAN RADIOLOGY, 2006, 16 (10) :2234-2241
[3]   Evaluation of a Thyroid Nodule [J].
Bomeli, Steven R. ;
LeBeau, Shane O. ;
Ferris, Robert L. .
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2010, 43 (02) :229-+
[4]   Assessing tumor angiogenesis using macromolecular MR imaging contrast media [J].
Brasch, R ;
Pham, C ;
Shames, D ;
Roberts, T ;
vanDijke, K ;
vanBruggen, N ;
Mann, J ;
Ostrowitzki, S ;
Melnyk, O .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (01) :68-74
[5]   Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF) [J].
Cyran, Clemens C. ;
Sennino, Barbara ;
Fu, Yanjun ;
Rogut, Victor ;
Shames, David M. ;
Chaopathomkul, Bundit ;
Wendland, Michael F. ;
McDonald, Donald M. ;
Brasch, Robert C. ;
Raatschen, Hans-Juergen .
EUROPEAN JOURNAL OF RADIOLOGY, 2012, 81 (05) :891-896
[6]  
EZZAT S, 1994, ARCH INTERN MED, V154, P1838
[7]   FINE-NEEDLE ASPIRATION BIOPSY OF THE THYROID - AN APPRAISAL [J].
GHARIB, H ;
GOELLNER, JR .
ANNALS OF INTERNAL MEDICINE, 1993, 118 (04) :282-289
[8]   Role of dynamic MRI in differentiating benign from malignant follicular thyroid nodule [J].
Gupta, Nikhil ;
Norbu, Choden ;
Goswami, Binita ;
Chowdhury, Veena ;
RaviShankar, L. ;
Gulati, Praveen ;
Kakar, Arun .
AURIS NASUS LARYNX, 2011, 38 (06) :718-723
[9]   Dynamic contrast-enhanced MRI for prostate cancer localization [J].
Jackson, A. S. N. ;
Reinsberg, S. A. ;
Sohaib, S. A. ;
Charles-Edwards, E. M. ;
Jhavar, S. ;
Christmas, T. J. ;
Thompson, A. C. ;
Bailey, M. J. ;
Corbishley, C. M. ;
Fisher, C. ;
Leach, M. O. ;
Dearnaley, D. P. .
BRITISH JOURNAL OF RADIOLOGY, 2009, 82 (974) :148-156
[10]   Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer [J].
Jo, Young Suk ;
Li, Shengjin ;
Song, Jung Hun ;
Kwon, Ki Hyun ;
Lee, Jun Chul ;
Rha, So Young ;
Lee, Hyo Jin ;
Sul, Ji Young ;
Kweon, Gi Ryang ;
Ro, Heung-kyu ;
Kim, Jin-Man ;
Shong, Minho .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) :3667-3670