Crucial steps to life: From chemical reactions to code using agents

被引：23
作者：
Witzany, Guenther [1 ]
机构：
[1] Telos Philosoph Praxis, Vogelsangstr 18c, A-5111 Buermoos, Austria
来源：
BIOSYSTEMS | 2016年 / 140卷
关键词：
Non-coding RNAs; Repeat sequences; Genetic parasites; Natural code users; NATURAL SELF-ORGANIZATION; NONCODING RNAS; REPETITIVE DNA; EVOLUTION; ORIGIN; SELECTION; SEQUENCES; RIBOZYMES; RIBOSOME; BEHAVIOR;
D O I：
10.1016/j.biosystems.2015.12.007
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the "central dogma," "one gene one protein" and "non-coding DNA is junk" were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage. Additionally the abundance of empirical data concerning non-random genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not fit with the dominant narrative of error replication events (mutations) as being the main driving forces creating genetic novelty and diversity. The reductionistic and mechanistic views on physico-chemical properties of the genetic code are no longer convincing as appropriate descriptions of the abundance of non-random genetic content operators which are active in natural genetic engineering and natural genome editing. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：49 / 57
页数：9
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