Waterpipe tobacco smoke distresses cardiovascular biomarkers in mice: alterations in protein expression of metalloproteinases, endothelin and myeloperoxidase

被引:12
作者
Rababa'h, Abeer M. [1 ]
Bsoul, Raghad W. [1 ]
Alkhatatbeh, Mohammad J. [1 ]
Alzoubi, Karem H. [1 ]
Khabour, Omar F. [2 ]
机构
[1] Jordan Univ Sci & Technol, Dept Clin Pharm, Fac Pharm, Irbid, Jordan
[2] Jordan Univ Sci & Technol, Fac Appl Med Sci, Dept Med Lab Sci, Irbid, Jordan
关键词
Atherosclerotic biomarkers; cardiovascular diseases; matrix metalloproteinase; waterpipe; endothelin; POLYCYCLIC AROMATIC-HYDROCARBONS; HUMAN MATRIX METALLOPROTEINASE-1; CORONARY-ARTERY-DISEASE; TISSUE INHIBITORS; CIGARETTE-SMOKING; OXIDATIVE STRESS; MAINSTREAM SMOKE; CARBON-MONOXIDE; EXPOSURE; PIPE;
D O I
10.1080/08958378.2019.1606366
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investigates toxic effects of WPS is essential. The aim of this study was to investigate the effect of WPS on major cardiovascular biomarkers that may develop atherosclerosis in mice. Methods: BALB/c mice were exposed to WPS for either two weeks (acute exposure) or eight weeks (chronic exposure). Then, the heart tissue homogenates were analyzed to elucidate the effects of WPS on matrix metalloproteinase (MMPs: isoforms 1, 3, and 9), metallopeptidase inhibitor (TIMP1), endothelin-1 (ET-1) and myeloperoxidase (MPO) using ELISA technique. Results: Current data showed that acute exposure to WPS significantly enhanced the levels of MMP-3, MMP-9, and MPO (p < 0.05) compared to their corresponding control. However, the body was capable to restore the increased levels of these parameters following chronic exposure to WPS for 8 weeks (p > 0.05). Additionally, the levels of ET-1 were significantly higher upon chronic exposure to WPS compared to both control and acute exposure groups (p < 0.05). Conclusions: Waterpipe exposure has a significant negative effect on the cardiovascular system. The enhancement of the atherosclerotic biomarkers (MMP-3, MMP-9, MPO, and ET-1) might represent an early scavenger of compensatory efforts to maintain cardiovascular function after WPS exposure.
引用
收藏
页码:99 / 106
页数:8
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