An efficient synthesis of benzodiazepine derivatives via a one-pot, three-component reaction accelerated by a chitosan-supported superparamagnetic iron oxide nanocomposite

被引：83

作者：

Maleki, Ali ^{[1
]}

Kamalzare, Maryam ^{[1
]}

机构：

[1] Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 50期

关键词：

Multicomponent reactions; Nanocomposite; Chitosan; Fe3O4; Benzodiazepine; SOLVENT-FREE CONDITIONS; 1,5-BENZODIAZEPINE DERIVATIVES; MULTICOMPONENT SYNTHESIS; MICROWAVE IRRADIATION; TERMINAL ALKYNES; MILD CONDITIONS; CATALYST; NANOPARTICLES; NANOCATALYST; TRIFLATE;

D O I：

10.1016/j.tetlet.2014.10.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work describes the catalytic ability of Fe3O4@chitosan as an environmentally benign and stable composite nanocatalyst for the synthesis of benzodiazepine derivatives starting from o-phenylenediamine, dimedone, and different aldehydes via a one-pot, three-component reaction at room temperature. High-to-excellent yields, easy work-up, reusability of the nanocatalyst, and non-toxicity are some of the advantages of this protocol. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6931 / 6934

页数：4

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